Evidence map›Paper›PMID 32467317›Full record

ArticleLife science alliance2020

Structural basis of HapE

Peter Hortschansky, Matthias Misslinger, Jasmin Mörl, Fabio Gsaller, Michael J Bromley, Axel A Brakhage, Michael Groll, Hubertus Haas, Eva M Huber

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Directed evolution of the pathogenic moldAntimicrobial agents and chemotherapy · 2026
    Article
  2. Review
  3. Role of the putativeMicrobial cell (Graz, Austria) · 2025
    Article
  4. Molecular Identification ofInfection and drug resistance · 2025
    Article
  5. Article
  6. The Transcriptome Response to Azole Compounds inJournal of fungi (Basel, Switzerland) · 2023
    Article
  7. Article
  8. Microbiology spectrum · 2023
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Peter HortschanskyDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), and Friedrich Schiller University Jena, Jena, Germany.ORCID 0000-0001-5194-9054
Matthias MisslingerInstitute of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria.
Jasmin MörlInstitute of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria.
Fabio GsallerInstitute of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria.
Michael J BromleyManchester Fungal Infection Group, Institute of Inflammation and Repair, University of Manchester, Manchester, UK.
Axel A BrakhageDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), and Friedrich Schiller University Jena, Jena, Germany.
Michael GrollCenter for Integrated Protein Science Munich at the Department Chemistry, Technical University of Munich, Garching, Germany.
Hubertus HaasInstitute of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria.
Eva M HuberCenter for Integrated Protein Science Munich at the Department Chemistry, Technical University of Munich, Garching, Germany eva.huber@tum.de.ORCID 0000-0001-8018-7204
Innsbruck Medical University · ATCenter for Integrated Protein Science Munich · DELeibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) · DEUniversity of Manchester · GB

Funding

Elevated gene transcription of the cyp51A gene is essential for azole drug resistance in Aspergillus fumigatusR01AI143198 · NIAID · UNIVERSITY OF IOWA · PI W Scott Moye-Rowley · 2019 to 2026
$3.9M
NIAID NIH HHS R01 AI143198Wellcome TrustWellcome Trust 208396/Z/17/Z
6 · The paper itself

Abstract

Azoles are first-line therapeutics for human and plant fungal infections, but their broad use has promoted the development of resistances. Recently, a pan-azole-resistant clinical

Indexed as

Drug Resistance, FungalMutationAmino Acid SequenceAntifungal AgentsAspergillus fumigatusAzolesBase SequenceCCAAT-Binding FactorFungal ProteinsMolecular ConformationStructure-Activity RelationshipAntifungal AgentsAzolesCCAAT-Binding FactorFungal Proteins

Identifiers

PMID32467317
PMCPMC7266990
OpenAlexW3029414443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.