Evidence map›Paper›PMID 32467181›Full record

SynthesisAJNR. American journal of neuroradiology2020

Long-Term Rupture Risk in Patients with Unruptured Intracranial Aneurysms Treated with Endovascular Therapy: A Systematic Review and Meta-Analysis.

A Rizvi, S M Seyedsaadat, M Alzuabi, M H Murad, R Kadirvel, W Brinjikji, D F Kallmes

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in AJNR. American journal of neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Flow diverter stents in the treatment of recanalized intracranial aneurysms.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

A RizviFrom the Department of Radiology (A.R., S.M.S., M.A., R.K., W.B., D.F.K.) drasimrizvi@gmail.com.ORCID 0000-0002-7046-4455
S M SeyedsaadatFrom the Department of Radiology (A.R., S.M.S., M.A., R.K., W.B., D.F.K.).ORCID 0000-0002-8219-6144
M AlzuabiFrom the Department of Radiology (A.R., S.M.S., M.A., R.K., W.B., D.F.K.).ORCID 0000-0002-2748-3474
M H MuradEvidence-Based Practice Center (M.H.M.), Mayo Clinic, Rochester, Minnesota.ORCID 0000-0001-5502-5975
R KadirvelFrom the Department of Radiology (A.R., S.M.S., M.A., R.K., W.B., D.F.K.).ORCID 0000-0002-6786-9953
W BrinjikjiFrom the Department of Radiology (A.R., S.M.S., M.A., R.K., W.B., D.F.K.).ORCID 0000-0001-5271-5524
D F KallmesFrom the Department of Radiology (A.R., S.M.S., M.A., R.K., W.B., D.F.K.).ORCID 0000-0002-8495-0040

Funding

Computational and Biological Approach to Flow DiversionR01NS076491 · NINDS · MAYO CLINIC ROCHESTER · PI Juan R Cebral, DAVID F KALLMES · 2011 to 2026
$7.4M
Enhanced endothelialization of nanomatrix coated flow diverter for intracranial aneurysmsR43NS110114 · NINDS · ENDOMIMETICS, LLC · PI HWANG, PATRICK, KADIRVEL, RAMANATHAN · 2019 to 2019
$563k
NINDS NIH HHS R01 NS076491NINDS NIH HHS R43 NS110114
6 · The paper itself

Abstract

backgroundSurveillance imaging of previously unruptured, coiled aneurysms remains routine even though reports of rupture of these aneurysms are extremely rare. PURPOSE: We performed meta-analysis to examine long-term rupture risk over ≥1-year follow-up duration in patients with unruptured intracranial aneurysm who underwent endovascular therapy. DATA SOURCES: Multiple databases were searched for relevant publications between 1995 and 2018. STUDY SELECTION: Studies reporting outcome of long-term rupture risk over ≥1-year follow-up in treated patients with unruptured intracranial aneurysms were included. DATA ANALYSIS: Random effects meta-analysis was used, and results were expressed as long-term rupture rate per 100 patient-year with respective 95% CIs. For ruptured aneurysms during follow-up, data were collected on size and completeness of initial Treatment. DATA SYNTHESIS: Twenty-four studies were identified. Among 4842 patients with a mean follow-up duration of 3.2 years, a total of 12 patients (0.25%) experienced rupture of previous unruptured intracranial aneurysms after endovascular treatment. Nine of these 12 patients harbored aneurysms that were large, incompletely treated, or both. A total of 2 anterior circulation, small, completely coiled aneurysms subsequently ruptured. The long-term rupture rate per 100 patient-year for unruptured intracranial aneurysms treated with endovascular therapy was 0.48 (95% CI, 0.45-0.51). Retreatment was carried out in 236 (4.9%) of these 4842 patients. LIMITATIONS: A limitation of the study is that a lack of systematic nature of follow-up and mean follow-up duration of 3.2 years are not sufficient to make general recommendations about aneurysm followup paradigms.

conclusionsGiven a 5% retreatment rate, postcoil embolization spontaneous rupture of previously unruptured, small- and medium-sized, well-treated aneurysms is exceedingly rare.

Indexed as

AdultAgedAneurysm, RupturedEmbolization, TherapeuticEndovascular ProceduresFemaleHumansIntracranial AneurysmMaleMiddle AgedRupture, SpontaneousTreatment Outcome

Identifiers

PMID32467181
PMCPMC7342755

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.