Evidence map›Paper›PMID 32467170›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Metal-induced sensor mobilization turns on affinity to activate regulator for metal detoxification in live bacteria.

Bing Fu, Kushal Sengupta, Lauren A Genova, Ace George Santiago, Won Jung, Łukasz Krzemiński, Udit Kumar Chakraborty, Wenyao Zhang, Peng Chen

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Genomic Characterization ofPlants (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Regulatory Characterization of Two Cop Systems for Copper Resistance inInternational journal of molecular sciences · 2025
    Article
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  7. Article
  8. Review
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  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Bing FuDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.ORCID 0000-0001-9952-2244
Kushal SenguptaDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.ORCID 0000-0002-5941-406X
Lauren A GenovaDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.ORCID 0000-0001-6594-2398
Ace George SantiagoDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
Won JungDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.ORCID 0000-0003-2810-5528
Łukasz KrzemińskiDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
Udit Kumar ChakrabortyDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
Wenyao ZhangDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
Peng ChenDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853 pc252@cornell.edu.ORCID 0000-0001-8582-7661
Cornell University · US

Funding

CHEMISTRY OF BIOLOGICAL SYSTEMST32GM008500 · NIGMS · CORNELL UNIVERSITY ITHACA · PI LIN, HENING · 1996 to 2020
$5.4M
Unusual mechanisms of metal regulation in bacteria: from single molecules to single cells to cell communitiesR01GM109993 · NIGMS · CORNELL UNIVERSITY · PI Peng Chen · 2014 to 2026
$3.9M
Broad wavelength range Zeiss 780 NLO/confocal system for the Cornell Imaging CoreS10OD018516 · OD · CORNELL UNIVERSITY · PI ZIPFEL, WARREN R · 2014 to 2014
$834k
Single-cell Imaging of Mechanically Coupled Assembly of Metal Efflux Complexes in BacteriaF31AI143208 · NIAID · CORNELL UNIVERSITY · PI GENOVA, LAUREN A · 2019 to 2020
$72k
NIAID NIH HHS F31 AI143208NIGMS NIH HHS R01 GM109993NIGMS NIH HHS T32 GM008500NIH HHS S10 OD018516
6 · The paper itself

Abstract

Metal detoxification is essential for bacteria's survival in adverse environments and their pathogenesis in hosts. Understanding the underlying mechanisms is crucial for devising antibacterial treatments. In the Gram-negative bacterium

Indexed as

Adenosine TriphosphateBinding SitesCell MembraneCopperCytoplasmEscherichia coliEscherichia coli ProteinsHistidine KinaseInactivation, MetabolicPeriplasmPhosphorylationProtein BindingProtein DomainsSignal TransductionSingle Molecule ImagingTrans-ActivatorsAdenosine TriphosphateCopperCusR protein, E coliEscherichia coli ProteinsHistidine KinaseTrans-Activatorsmetal regulationprotein interactionssignal transductionsingle-molecule trackingtwo-component system

Identifiers

PMID32467170
PMCPMC7306728
OpenAlexW3032859417

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.