Evidence map›Paper›PMID 32467169›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

A family of hyperpolarization-activated channels selective for protons.

Lea Wobig, Thérèse Wolfenstetter, Sylvia Fechner, Wolfgang Bönigk, Heinz G Körschen, Jan F Jikeli, Christian Trötschel, Regina Feederle, U Benjamin Kaupp, Reinhard Seifert and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Soluble adenylyl cyclase in nonmammalian sperm is directly controlled by pH, not by HCOProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Proton-selective conductance and gating of the lysosomal cation channel TMEM175.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Voltage sensors.Molecular pharmacology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Transcendent Aspects of Proton Channels.Annual review of physiology · 2024
    Review
  13. Article
  14. Review
  15. Article
  16. Reconstruction of the birth of a male sex chromosome present in Atlantic herring.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Lea WobigDepartment of Molecular Sensory Systems, Research Center Caesar, 53175 Bonn, Germany.ORCID 0000-0002-3234-7928
Thérèse WolfenstetterDepartment of Molecular Sensory Systems, Research Center Caesar, 53175 Bonn, Germany.
Sylvia FechnerDepartment of Molecular Sensory Systems, Research Center Caesar, 53175 Bonn, Germany.ORCID 0000-0003-4440-6611
Wolfgang BönigkDepartment of Molecular Sensory Systems, Research Center Caesar, 53175 Bonn, Germany.
Heinz G KörschenDepartment of Molecular Sensory Systems, Research Center Caesar, 53175 Bonn, Germany.
Jan F JikeliDepartment of Molecular Sensory Systems, Research Center Caesar, 53175 Bonn, Germany.
Christian TrötschelDepartment of Plant Biochemistry, Ruhr-University Bochum, 44801 Bochum, Germany.
Regina FeederleMonoclonal Antibody Core Facility and Research Group, Institute for Diabetes and Obesity, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0002-3981-367X
U Benjamin KauppDepartment of Molecular Sensory Systems, Research Center Caesar, 53175 Bonn, Germany; u.b.kaupp@caesar.de reinhard.seifert@caesar.de thomas.berger@uni-marburg.de.ORCID 0000-0002-0696-6397
Reinhard SeifertDepartment of Molecular Sensory Systems, Research Center Caesar, 53175 Bonn, Germany; u.b.kaupp@caesar.de reinhard.seifert@caesar.de thomas.berger@uni-marburg.de.
Thomas K BergerDepartment of Molecular Sensory Systems, Research Center Caesar, 53175 Bonn, Germany; u.b.kaupp@caesar.de reinhard.seifert@caesar.de thomas.berger@uni-marburg.de.ORCID 0000-0001-9358-1315
Center of Advanced European Studies and Research · DEHelmholtz Zentrum München · DEPhilipps University of Marburg · DERuhr University Bochum · DEUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proton (H

Indexed as

Amino Acid SequenceAnimalsBiological TransportMaleMultigene FamilyProtonsSpermatozoaZebrafishProtonsHCN channelHCNL1 channelproton channelvoltage-sensing domain

Identifiers

PMID32467169
PMCPMC7306766
OpenAlexW3029170436

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.