Evidence map›Paper›PMID 32467168›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Anisotropy links cell shapes to tissue flow during convergent extension.

Xun Wang, Matthias Merkel, Leo B Sutter, Gonca Erdemci-Tandogan, M Lisa Manning, Karen E Kasza

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 180 citations in OpenAlex.

  1. Cell jamming transition is regulated by mitochondrial pyruvate transport and endocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  13. bioRxiv : the preprint server for biology · 2026
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  19. Dynamic forces drive cell and organ morphology changes during embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Tunable shear thickening, aging, and rejuvenation in suspensions of shape-memory-endowed liquid crystalline particles.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Xun WangDepartment of Mechanical Engineering, Columbia University, New York, NY 10027.ORCID 0000-0002-6363-4225
Matthias MerkelDepartment of Physics, Syracuse University, Syracuse, NY 13244.ORCID 0000-0001-9118-1270
Leo B SutterDepartment of Physics, Syracuse University, Syracuse, NY 13244.
Gonca Erdemci-TandoganDepartment of Physics, Syracuse University, Syracuse, NY 13244.
M Lisa ManningDepartment of Physics, Syracuse University, Syracuse, NY 13244.ORCID 0000-0001-7682-2324
Karen E KaszaDepartment of Mechanical Engineering, Columbia University, New York, NY 10027; karen.kasza@columbia.edu.ORCID 0000-0002-0888-3579
Syracuse University · USColumbia University · USCentre National de la Recherche Scientifique · FR

Funding

Quantitative Modeling of Cell Shape Changes During OrganogenesisR01GM117598 · NIGMS · SYRACUSE UNIVERSITY · PI MANNING, MARY ELIZABETH LISA · 2015 to 2018
$1.0M
NIGMS NIH HHS R01 GM117598
6 · The paper itself

Abstract

Within developing embryos, tissues flow and reorganize dramatically on timescales as short as minutes. This includes epithelial tissues, which often narrow and elongate in convergent extension movements due to anisotropies in external forces or in internal cell-generated forces. However, the mechanisms that allow or prevent tissue reorganization, especially in the presence of strongly anisotropic forces, remain unclear. We study this question in the converging and extending

Indexed as

Cell ShapeAnimalsAnisotropyDrosophilaDrosophila ProteinsEpitheliumMyosin Type IIDrosophila ProteinsMyosin Type IIDrosophilaepitheliamorphogenesisvertex models

Identifiers

PMID32467168
PMCPMC7306759
OpenAlexW3030851154

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.