Evidence map›Paper›PMID 32466837›Full record

SynthesisJACC. Heart failure2020

Health Literacy and Outcomes Among Patients With Heart Failure: A Systematic Review and Meta-Analysis.

Matteo Fabbri, M Hassan Murad, Alexandra M Wennberg, Pierpaolo Turcano, Patricia J Erwin, Fares Alahdab, Alvise Berti, Sheila M Manemann, Kathleen J Yost, Lila J Finney Rutten and 1 more

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in JACC. Heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. The Effect of Health Literacy Interventions on Self-management in Chronic Diseases: A Systematic Review.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025
    Pooled it
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  15. Knowledge Gaps in Patients Undergoing Thyroid Fine-Needle Aspiration BiopsyEndocrine, metabolic & immune disorders drug targets · 2026
    Article
  16. Latent class analysis of quality of life among patients with Kashin-Beck disease and its association with health literacy and social support.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
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  20. Observational

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Matteo FabbriDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
M Hassan MuradRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Mayo Clinic Evidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota.
Alexandra M WennbergDepartment of Neurology, Mayo Clinic, Rochester, Minnesota.
Pierpaolo TurcanoDepartment of Neurology, Mayo Clinic, Rochester, Minnesota.
Patricia J ErwinMayo Clinic Libraries, Mayo Clinic, Rochester, Minnesota.
Fares AlahdabRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Mayo Clinic Evidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota.
Alvise BertiDepartment of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.
Sheila M ManemannDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Kathleen J YostDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota.
Lila J Finney RuttenDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota.
Véronique L RogerDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota. Electronic address: roger.veronique@mayo.edu.

Funding

Mayo Clinic Center for Clinical and Translational Science (CCaTS UL1 Supplement - Dr. Timothy Curry)UL1TR002377 · NCATS · MAYO CLINIC ROCHESTER · PI VESNA D GAROVIC · 2017 to 2026
$78.4M
'Heart Failure in the Community: Multimorbidity and Outcomes'R01HL120859 · NHLBI · MAYO CLINIC ROCHESTER · PI ROGER, VERONIQUE LEE · 2014 to 2017
$3.2M
NCATS NIH HHS UL1 TR002377NHLBI NIH HHS R01 HL120859
6 · The paper itself

Abstract

objectivesThe purpose of this study was to determine if health literacy is associated with mortality, hospitalizations, or emergency department (ED) visits among patients living with heart failure (HF).

backgroundGrowing evidence suggests an association between health literacy and health-related outcomes in patients with HF.

methodsWe searched Embase, MEDLINE, PsycINFO, and EBSCO CINAHL from inception through January 1, 2019, with the help of a medical librarian. Eligible studies evaluated health literacy among patients with HF and assessed mortality, hospitalizations, and ED visits for all causes with no exclusion by time, geography, or language. Two reviewers independently selected studies, extracted data, and assessed the methodological quality of the identified studies.

resultsWe included 15 studies, 11 with an overall high methodological quality. Among the observational studies, an average of 24% of patients had inadequate or marginal health literacy. Inadequate health literacy was associated with higher unadjusted risk for mortality (risk ratio [RR]: 1.67; 95% confidence interval [CI]: 1.18 to 2.36), hospitalizations (RR: 1.19; 95% CI: 1.09 to 1.29), and ED visits (RR: 1.17; 95% CI: 1.03 to 1.32). When the adjusted measurements were combined, inadequate health literacy remained statistically associated with mortality (RR: 1.41; 95% CI: 1.06 to 1.88) and hospitalizations (RR: 1.12; 95% CI: 1.01 to 1.25). Among the 4 interventional studies, 2 effectively improved outcomes among patients with inadequate health literacy.

conclusionsIn this study, the estimated prevalence of inadequate health literacy was high, and inadequate health literacy was associated with increased risk of death and hospitalizations. These findings have important clinical and public health implications and warrant measurement of health literacy and deployment of interventions to improve outcomes.

Indexed as

Health StatusEmergency Service, HospitalHealth LiteracyHeart FailureHospitalizationHumansQuality of LifeED visitshealth literacyheart failurehospitalizationmortality

Identifiers

PMID32466837
PMCPMC7263350

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.