Evidence map›Paper›PMID 32466757›Full record

ArticleBMC medicine2020

Ethnic and socioeconomic differences in SARS-CoV-2 infection: prospective cohort study using UK Biobank.

Claire L Niedzwiedz, Catherine A O'Donnell, Bhautesh Dinesh Jani, Evangelia Demou, Frederick K Ho, Carlos Celis-Morales, Barbara I Nicholl, Frances S Mair, Paul Welsh, Naveed Sattar and 2 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMC medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04505774 (A Multicenter, Adaptive, Randomized Controlled Platform Trial of the Safety and Efficacy of Antithrombotic and Additional Strategies in Hospitalized Adults With COVID-19), which is not on this map. Cited by 229 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
229citing papers in PubMed, 6 pooled it
9.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04505774 phase4completednot on this map

A Multicenter, Adaptive, Randomized Controlled Platform Trial of the Safety and Efficacy of Antithrombotic and Additional Strategies in Hospitalized Adults With COVID-19

TypeinterventionalSponsorMatthew Neal MDRan2020 to 2024Enrolled3,591ConditionsCovid19Armstheraputic heparin, prophylactic heparin, P2Y12, Crizanlizumab Injection, SGLT2 inhibitor
3 · Its place in the literature

Who cites it

229 citing papers in PubMed, 6 syntheses or guidelines pooled it, 419 citations in OpenAlex.

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  11. Drivers of COVID-19 infections: Perspectives of managers in the Gauteng Department of Health, South Africa.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2025
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169 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Claire L NiedzwiedzInstitute of Health & Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8RZ, UK.
Catherine A O'DonnellGeneral Practice and Primary Care, Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, 1 Horselethill Road, Glasgow, G12 9LX, UK.
Bhautesh Dinesh JaniGeneral Practice and Primary Care, Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, 1 Horselethill Road, Glasgow, G12 9LX, UK.
Evangelia DemouMRC/CSO Social & Public Health Sciences Unit, University of Glasgow, Top floor, 200 Renfield Street, Glasgow, G2 3QB, UK.
Frederick K HoInstitute of Health & Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8RZ, UK.
Carlos Celis-MoralesInstitute of Health & Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8RZ, UK.
Barbara I NichollGeneral Practice and Primary Care, Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, 1 Horselethill Road, Glasgow, G12 9LX, UK.
Frances S MairGeneral Practice and Primary Care, Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, 1 Horselethill Road, Glasgow, G12 9LX, UK.
Paul WelshBHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
Naveed SattarBHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
Jill P PellInstitute of Health & Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8RZ, UK.
S Vittal KatikireddiMRC/CSO Social & Public Health Sciences Unit, University of Glasgow, Top floor, 200 Renfield Street, Glasgow, G2 3QB, UK. vittal.katikireddi@glasgow.ac.uk.ORCID http://orcid.org/0000-0001-6593-9092
University of Glasgow · GBMRC/CSO Social and Public Health Sciences Unit · GB

Funding

Chief Scientist Office SCAF/15/02Chief Scientist Office SPHSU13Chief Scientist Office SPHSU17Medical Research Council MC_UU_00022/2Medical Research Council MC_UU_12017/13Medical Research Council MR/R024774/1
6 · The paper itself

Abstract

backgroundUnderstanding of the role of ethnicity and socioeconomic position in the risk of developing SARS-CoV-2 infection is limited. We investigated this in the UK Biobank study.

methodsThe UK Biobank study recruited 40-70-year-olds in 2006-2010 from the general population, collecting information about self-defined ethnicity and socioeconomic variables (including area-level socioeconomic deprivation and educational attainment). SARS-CoV-2 test results from Public Health England were linked to baseline UK Biobank data. Poisson regression with robust standard errors was used to assess risk ratios (RRs) between the exposures and dichotomous variables for being tested, having a positive test and testing positive in hospital. We also investigated whether ethnicity and socioeconomic position were associated with having a positive test amongst those tested. We adjusted for covariates including age, sex, social variables (including healthcare work and household size), behavioural risk factors and baseline health.

resultsAmongst 392,116 participants in England, 2658 had been tested for SARS-CoV-2 and 948 tested positive (726 in hospital) between 16 March and 3 May 2020. Black and south Asian groups were more likely to test positive (RR 3.35 (95% CI 2.48-4.53) and RR 2.42 (95% CI 1.75-3.36) respectively), with Pakistani ethnicity at highest risk within the south Asian group (RR 3.24 (95% CI 1.73-6.07)). These ethnic groups were more likely to be hospital cases compared to the white British. Adjustment for baseline health and behavioural risk factors led to little change, with only modest attenuation when accounting for socioeconomic variables. Socioeconomic deprivation and having no qualifications were consistently associated with a higher risk of confirmed infection (RR 2.19 for most deprived quartile vs least (95% CI 1.80-2.66) and RR 2.00 for no qualifications vs degree (95% CI 1.66-2.42)).

conclusionsSome minority ethnic groups have a higher risk of confirmed SARS-CoV-2 infection in the UK Biobank study, which was not accounted for by differences in socioeconomic conditions, baseline self-reported health or behavioural risk factors. An urgent response to addressing these elevated risks is required.

Indexed as

BetacoronavirusBiological Specimen BanksHealth Status DisparitiesSevere acute respiratory syndrome-related coronavirusAdultCoronavirus InfectionsCOVID-19EthnicityFemaleHumansMaleMiddle AgedPandemicsPneumonia, ViralResidence CharacteristicsRisk FactorsCoronavirusCOVID-19EthnicityHealth inequalityInequalityInfectious diseasePandemicSARS-CoV-2Social factors

Identifiers

PMID32466757
PMCPMC7255908
OpenAlexW3031193631

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.