Evidence map›Paper›PMID 32466613›Full record

ArticleGenes2020

Interpreting Mixture Profiles: Comparison between Precision ID GlobalFiler™ NGS STR Panel v2 and Traditional Methods.

Michele Ragazzo, Stefania Carboni, Valerio Caputo, Carlotta Buttini, Laura Manzo, Valeria Errichiello, Giulio Puleri, Emiliano Giardina

Open access · goldAbstract read
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Michele RagazzoDepartment of Biomedicine and Prevention, Tor Vergata University of Rome, 00133 Rome, Italy.
Stefania CarboniGenomic Medicine Laboratory UILDM, Santa Lucia Foundation IRCCS, 00142 Rome, Italy.
Valerio CaputoDepartment of Biomedicine and Prevention, Tor Vergata University of Rome, 00133 Rome, Italy.ORCID 0000-0002-3503-3318
Carlotta ButtiniDepartment of Biomedicine and Prevention, Tor Vergata University of Rome, 00133 Rome, Italy.
Laura ManzoDepartment of Biomedicine and Prevention, Tor Vergata University of Rome, 00133 Rome, Italy.
Valeria ErrichielloDepartment of Biomedicine and Prevention, Tor Vergata University of Rome, 00133 Rome, Italy.
Giulio PuleriDepartment of Biomedicine and Prevention, Tor Vergata University of Rome, 00133 Rome, Italy.
Emiliano GiardinaDepartment of Biomedicine and Prevention, Tor Vergata University of Rome, 00133 Rome, Italy.
University of Rome Tor Vergata · ITFondazione Santa Lucia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Forensic investigation for the identification of offenders, recognition of human remains, and verification of family relationships requires the analysis of particular types of highly informative DNA markers, which have high discriminatory power and are efficient for typing degraded samples. These markers, called STRs (Short Tandem Repeats), can be amplified by multiplex-PCR (Polymerase Chain Reaction) allowing attainment of a unique profile through which it is possible to distinguish one individual from another with a high statistical significance. The rapid and progressive evolution of analytical techniques and the advent of Next-Generation Sequencing (NGS) have completely revolutionized the DNA sequencing approach. This technology, widely used today in the diagnostic field, has the advantage of being able to process several samples in parallel, producing a huge volume of data in a short time. At this time, although default parameters of interpretation software are available, there is no general agreement on the interpretation rules of forensic data produced via NGS technology. Here we report a pilot study aimed for a comparison between NGS (Precision ID GlobalFiler™ NGS STR Panel v2,

Indexed as

Forensic GeneticsHigh-Throughput Nucleotide SequencingBody RemainsDNADNA FingerprintingGenetic MarkersHumansMicrosatellite RepeatsMultiplex Polymerase Chain ReactionPolymorphism, Single NucleotideSalivaUrineDNAGenetic MarkersDNA typingforensic genomicsmixturesnext-generation sequencing (NGS)

Identifiers

PMID32466613
PMCPMC7349666
OpenAlexW3032409962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.