ArticleInternational journal of molecular sciences2020
Nicotinamide Mononucleotide Administration Prevents Experimental Diabetes-Induced Cognitive Impairment and Loss of Hippocampal Neurons.
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Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- A systematic review of the therapeutic potential of nicotinamide adenine dinucleotide precursors for cognitive diseases in preclinical rodent models.BMC neuroscience · 2025Pooled it
- Therapeutic effects of nicotinamide mononucleotide and Indian gooseberry in oxidative stress and inflammation-induced damage on human retinal pigment epithelial cells: A pilot study.Journal of biomedical research · 2026Article
- Aging Triggers an Intestinal Energy Crisis and HDL3 Deficiency Disrupting Gut-Liver Axis Homeostasis.Aging cell · 2026Article
- Targeting the sirtuin 6-NF-κB p65 axis by 6-hydroxyhyoscyamine hydrobromide: a deacetylation-driven new therapy for diabetic wounds.Cellular & molecular biology letters · 2026Article
- AMPK/SIRT1/PGC-1α Signaling Pathway: Molecular Mechanisms and Targeted Strategies From Energy Homeostasis Regulation to Disease Therapy.CNS neuroscience & therapeutics · 2025Review
- TNF-α Inhibition Modulates CX3CR1, Pyroptosis-related Genes, and BDNF to Alleviate Anxiety-like Behavior in Type 2 Diabetic Rats.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Effects of 8-Week High-Intensity Interval Training Intervention Regulating the SIRT1/PGC1α Pathway on Hippocampal Neuron Injury and Cognitive Impairment in Obese Rats.Current developments in nutrition · 2025Article
- From bench to bedside: therapeutic potential of natural antioxidants in diabetic neuropathy.Frontiers in cell and developmental biology · 2025Review
- Cross-regulation between adipose tissue innervation and metaflammation: a potential therapeutic target for obesity.American journal of translational research · 2025Review
- Pathobiochemistry of Aging and Neurodegeneration: Deregulation of NAD+ Metabolism in Brain Cells.Biomolecules · 2024Review
- Polydatin and Nicotinamide Rescue the Cellular Phenotype of Mitochondrial Diseases by Mitochondrial Unfolded Protein Response (mtUPR) Activation.Biomolecules · 2024Article
- Non-invasive in vivo measurements of metabolic alterations in the type 2 diabetic brain byJournal of neurochemistry · 2024Article
- NADInternational journal of molecular sciences · 2024Article
- Article
- The Combination of Citicoline and Nicotinamide Mononucleotide Induces Neurite Outgrowth and Mitigates Vascular Cognitive Impairment via SIRT1/CREB Pathway.Cellular and molecular neurobiology · 2023Article
- Lactoferrin deficiency during lactation increases the risk of depressive-like behavior in adult mice.BMC biology · 2023Article
- Hippocampal proteins discovery of Panax quinquefolius and Acorus gramineus ameliorating cognitive impairment in diabetic rats.Psychopharmacology · 2023Article
- Technology and functional insights into the nicotinamide mononucleotide for human health.Applied microbiology and biotechnology · 2023Review
- Nicotinamide Prevents Diabetic Brain Inflammation via NAD+-Dependent Deacetylation Mechanisms.Nutrients · 2023Article
- Dietary Polyphenols as a Protection against Cognitive Decline: Evidence from Animal Experiments; Mechanisms and Limitations.Antioxidants (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Krish ChandrasekaranDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Joungil ChoiDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Muhammed Ikbal ArvasDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Mohammad SalimianDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Sujal SinghDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Su XuDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Rao P GullapalliDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Tibor KristianVeterans Affairs Medical Center, Baltimore, MD 21201, USA.
James William RussellDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
University of Maryland, Baltimore · USVeterans Health Administration · US
Funding
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3MNAD+ and SIRT1 Regulate Mitochondrial Function in Diabetic NeuropathyR01DK107007 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI RUSSELL, JAMES W · 2016 to 2021
$2.3MEFFECT OF TOXIC AGENTS ON VITAMIN A STATUSF06TW001030 · FIC · IOWA STATE UNIVERSITY · PI OLSON, JAMES A · 1985 to 1985
–The role of nicotinamide mononucleotide dependent mitochondrial reactive oxygen species generation in acute brain injuryI01BX004895 · VA · BALTIMORE VA MEDICAL CENTER · PI KRISTIAN, TIBOR · 2020 to 2024
–Atlantic Nutrition Obesity Research Center, grant P30, NIDDK, NIH DK072488BLRD VA I01 BX004895NIDDK NIH HHS 1R01DK107007-01A1Office of Research Development, Department of Veterans Affairs 101RX001030Office of Research Development, Department of Veterans Affairs BX000917 (T.K.)
Abstract
Diabetes predisposes to cognitive decline leading to dementia and is associated with decreased brain NAD
Indexed as
AnimalsAspartic AcidCognitive DysfunctionDiabetes Complicationsgamma-Aminobutyric AcidGlucoseGlutamic AcidHippocampusInjections, IntraperitonealMaleMemoryNADNedd4 Ubiquitin Protein LigasesNeuroprotective AgentsNicotinamide MononucleotidePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaAspartic Acidgamma-Aminobutyric AcidGlucoseGlutamic AcidN-acetylaspartateNADNedd4 protein, ratNedd4 Ubiquitin Protein LigasesNeuroprotective AgentsNicotinamide MononucleotidePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, ratSirtuin 1Taurinecognitive impairmentdementiadiabetesmitochondriaNAD+NEDD4-1NMNPGC-1αSIRT1
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.