Evidence map›Paper›PMID 32466161›Full record

ArticleNutrients2020

Nutraceutical Effects of Lycopene in Experimental Varicocele: An "In Vivo" Model to Study Male Infertility.

Pietro Antonuccio, Antonio Micali, Domenico Puzzolo, Carmelo Romeo, Giovanna Vermiglio, Violetta Squadrito, Jose Freni, Giovanni Pallio, Vincenzo Trichilo, Maria Righi and 5 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Lycopene in male infertility.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Lycopene andPharmaceuticals (Basel, Switzerland) · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Testicular toxicity of cisplatin in rats: ameliorative effect of lycopene and N-acetylcysteine.Environmental science and pollution research international · 2022
    Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Pietro AntonuccioDepartment of Human Pathology of Adult and Childhood, University of Messina, 98125 Messina, Italy.
Antonio MicaliDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy.
Domenico PuzzoloDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy.
Carmelo RomeoDepartment of Human Pathology of Adult and Childhood, University of Messina, 98125 Messina, Italy.
Giovanna VermiglioDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy.
Violetta SquadritoDepartment of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
Jose FreniDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy.
Giovanni PallioDepartment of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
Vincenzo TrichiloDepartment of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
Maria RighiDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy.
Natasha IrreraDepartment of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
Domenica AltavillaDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy.
Francesco SquadritoDepartment of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
Herbert R MariniDepartment of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
Letteria MinutoliDepartment of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
University of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Varicocele is one of the main causes of infertility in men. Oxidative stress and consequently apoptosis activation contribute to varicocele pathogenesis, worsening its prognosis. Natural products, such as lycopene, showed antioxidant and anti-inflammatory effects in several experimental models, also in testes. In this study we investigated lycopene effects in an experimental model of varicocele. Male rats (

Indexed as

Dietary SupplementsAnimalsAntioxidantsApoptosisbcl-2-Associated X ProteinCarotenoidsInfertility, MaleIn Situ Nick-End LabelingLycopeneMaleMalondialdehydeOxidative StressProto-Oncogene Proteins c-bcl-2RatsRats, Sprague-DawleyTestisAntioxidantsBax protein, ratbcl-2-Associated X ProteinBcl2 protein, ratCarotenoidsLycopeneMalondialdehydeProto-Oncogene Proteins c-bcl-2Testosteroneapoptosiscarotenoidsdietlycopenenutraceuticalsoxidative stressrattestisvaricocele

Identifiers

PMID32466161
PMCPMC7284888
OpenAlexW3028421468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.