ReviewDiagnostics (Basel, Switzerland)2020
The Diagnostic Dilemma of Malignant Biliary Strictures.
Review in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06115655 (A Single-center, Prospective Cohort Study on the Differentiation of Benign and Malignant Bile Duct Stenosis Based on Bile and Peripheral Blood cfDNA Methylation Profiles), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Single-center, Prospective Cohort Study on the Differentiation of Benign and Malignant Bile Duct Stenosis Based on Bile and Peripheral Blood cfDNA Methylation Profiles
Who cites it
19 citing papers in PubMed.
- Diagnostic value of peroral choledochoscopy combined with modified biopsy forceps for malignant biliary strictures: a two-center retrospective study.Surgical endoscopy · 2026Article
- Two Cases of Benign Biliary Stricture in Young Men.Cureus · 2026Article
- The role of ROSE-enhanced ERCP-guided biopsy in diagnosing biliary stricture.Scientific reports · 2025Article
- Point-of-Care Testing and Biomarkers in Biliary Diseases: Current Evidence and Future Directions.Journal of clinical medicine · 2025Review
- Diagnostic Accuracy Performance of Fluorescence In Situ Hybridization (FISH) for Biliary Strictures: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Case report: The diagnostic dilemma of indeterminate biliary strictures: report on two cases with a literature review.Frontiers in oncology · 2024Article
- Management of an iatrogenic duodenal perforation with a helical tack system in a patient with pancreatic cancer complicated by gastric outlet obstruction.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2023Article
- Role of peroral cholangioscopy and pancreatoscopy in the diagnosis and treatment of biliary and pancreatic disease: past, present, and future.Frontiers in gastroenterology (Lausanne, Switzerland) · 2023Review
- Preoperative evaluation of malignant pancreatobiliary obstruction: A novel technique for multiphase fusion 3D CT images.European journal of radiology open · 2023Article
- Metastatic Anal Squamous Cell Carcinoma Presenting as an Indeterminate Biliary Stricture Diagnosed By Cholangioscopy.ACG case reports journal · 2022Article
- Ultrasonographic evaluation of patients with abnormal liver function tests in the emergency department.Ultrasonography (Seoul, Korea) · 2022Article
- Diagnosis of malignant biliary obstruction: pondering over the ERCP, MRCP and histology.The Journal of international medical research · 2022Article
- Clinical characteristics, risk factors and diagnostic outcomes of patients presented with indeterminate biliary stricture: A multicenter study.Frontiers in medicine · 2022Article
- Approach to management of pancreatic strictures: the gastroenterologist's perspective.Clinical journal of gastroenterology · 2021Review
- Tissue Sampling through Endoscopic Ultrasound-Guided Fine Needle Aspiration versus Endoscopic Retrograde Cholangiopancreatographic Brushing Cytology Technique in Suspicious Malignant Biliary Stricture.Middle East journal of digestive diseases · 2021Article
- Predicting Malignancy of Biliary Stricture with a Nomogram in Patients with a Non-Malignant Endoscopic Tissue Diagnosis: A Retrospective Study.Cancer management and research · 2021Article
- Biliary Strictures and Cholangiocarcinoma - Untangling a Diagnostic Conundrum.Frontiers in oncology · 2021Review
- MRCP Combined With CT Promotes the Differentiation of Benign and Malignant Distal Bile Duct Strictures.Frontiers in oncology · 2021Article
- Antegrade Therapy for Management of Choledocholithiasis through Endoscopic Ultrasound-Guided Hepaticogastrostomy in a Patient with Surgically Altered Gastrointestinal Anatomy.Case reports in gastrointestinal medicine · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The differential diagnosis for biliary strictures is broad. However, the likelihood of malignancy is high. Determining the etiology of a biliary stricture requires a comprehensive physical exam, laboratory evaluation, imaging, and ultimately tissue acquisition. Even then, definitive diagnosis is elusive, and many strictures remain indeterminant in origin. This literary review examines the diagnostic dilemma of biliary strictures and presents innovations in both histochemical and endoscopic techniques that have increased the diagnostic power of differentiating benign and malignant strictures. The field of tissue biopsy is revolutionizing with the advent of free DNA mutation profiling, fluorescence in situ hybridization (FISH), and methionyl t-RNA synthetase 1 (MARS 1), which allow for greater testing sensitivity. Endoscopic ultrasound, endoscopic retrograde cholangiopancreatography (ERCP), cholangioscopy, confocal laser endomicroscopy, and intraductal ultrasound build upon existing endoscopic technology to better characterize strictures that would otherwise be indeterminate in etiology. This review uses recent literature to insert innovative technology into the traditional framework of diagnostic methods for malignant biliary strictures.
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