Evidence map›Paper›PMID 32464711›Full record

ReviewLiver international : official journal of the International Association for the Study of the Liver2020

New insights in the management of Hepatocellular Adenoma.

Anne J Klompenhouwer, Robert A de Man, Marco Dioguardi Burgio, Valerie Vilgrain, Jessica Zucman-Rossi, Jan N M Ijzermans

Open access · hybridAbstract readReview
In one paragraph

Review in Liver international : official journal of the International Association for the Study of the Liver, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. "Update on pediatric primary liver tumors".Virchows Archiv : an international journal of pathology · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. [Multidisciplinary experts consensus on diagnosis and treatment of precancerous lesions of hepatocellular carcinoma (2023 version)].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Hepatocellular adenoma: Where are we now?World journal of gastroenterology · 2022
    Article
  15. A Scoping Review of the Classification, Diagnosis, and Management of Hepatic Adenomas.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022
    Article
  16. Article
  17. New insights in the management of Hepatocellular Adenoma.Liver international : official journal of the International Association for the Study of the Liver · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Anne J KlompenhouwerDepartment of Surgery, Erasmus MC University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0002-6740-3862
Robert A de ManDepartment of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Marco Dioguardi BurgioDepartment of Radiology, Hauts-de-Seine, University Hospitals Paris Nord Val de Seine, Beaujon, APHP, Clichy, France.
Valerie VilgrainDepartment of Radiology, Hauts-de-Seine, University Hospitals Paris Nord Val de Seine, Beaujon, APHP, Clichy, France.
Jessica Zucman-RossiCentre de Recherche des Cordeliers, Sorbonne Université, INSERM, Université de Paris, Paris, France.
Jan N M IjzermansDepartment of Surgery, Erasmus MC University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0003-3558-1039
Erasmus MC · NLInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular adenoma (HCA) are benign liver tumours that may be complicated by haemorrhage or malignant transformation to hepatocellular carcinoma. Epidemiological data are fairly outdated, but it is likely to assume that the incidence has increased over the past decades as HCA are more often incidentally found due to the more widespread use of imaging techniques and the increased incidence of obesity. Various molecular subgroups have been described. Each of these molecular subgroups are defined by specific gene mutations and pathway activations. Additionally, they are all related to specific risk factors and show a various biological behaviour. These molecular subgroups may be identified using immunohistochemistry and molecular characterization. Contrast-enhanced MRI is the recommended imaging modality to analyse patients with suspected hepatocellular adenoma allowing to determine the subtype in up to 80%. Surgical resection remains to be the golden standard in treating HCA, although resection is deemed unnecessary in a large number of cases, as studies have shown that the majority of HCA will regress over time without complications such as haemorrhage or malignant transformation occurring. It is preferable to treat patients with suspected HCA in high volume centres with combined expertise of liver surgeons, hepatologists, radiologists and (molecular) pathologists.

Indexed as

Adenoma, Liver CellCarcinoma, HepatocellularLiver NeoplasmsHumansMagnetic Resonance ImagingHepatocellular Adenomamanagementreview

Identifiers

PMID32464711
PMCPMC7383747
OpenAlexW3032403665

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.