Evidence map›Paper›PMID 32464196›Full record

ArticleMechanisms of development2020

Mdm4 controls ureteric bud branching via regulation of p53 activity.

Sylvia A Hilliard, Yuwen Li, Angelina Dixon, Samir S El-Dahr

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mechanisms of development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sylvia A HilliardTulane University School of Medicine, Department of Pediatrics, Section of Pediatric Nephrology, New Orleans, LA 70112, United States of America.
Yuwen LiTulane University School of Medicine, Department of Pediatrics, Section of Pediatric Nephrology, New Orleans, LA 70112, United States of America.
Angelina DixonTulane University School of Medicine, Department of Pediatrics, Section of Pediatric Nephrology, New Orleans, LA 70112, United States of America.
Samir S El-DahrTulane University School of Medicine, Department of Pediatrics, Section of Pediatric Nephrology, New Orleans, LA 70112, United States of America. Electronic address: seldahr@tulane.edu.
Tulane University · US

Funding

TERMINAL DIFFERENTIATION OF THE RENAL EPITHELIUMR01DK062250 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI EL-DAHR, SAMIR S · 2003 to 2012
$2.5M
Epigenetic Control of Nephron Progenitor Cell LifespanR01DK114050 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI EL-DAHR, SAMIR S · 2017 to 2020
$1.4M
NIDDK NIH HHS R01 DK062250NIDDK NIH HHS R01 DK114050
6 · The paper itself

Abstract

The antagonism between Mdm2 and its close homolog Mdm4 (also known as MdmX) and p53 is vital for embryogenesis and organogenesis. Previously, we demonstrated that targeted disruption of Mdm2 in the Hoxb7+ ureteric bud (Ub) lineage, which gives rise to the renal collecting system, causes renal hypodysplasia culminating in perinatal lethality. In this study, we examine the unique role of Mdm4 in establishing the collecting duct system of the murine kidney. Hoxb7Cre driven loss of Mdm4 in the Ub lineage (Ub

Indexed as

AnimalsAnimals, NewbornApoptosisAxin ProteinCell LineageEmbryonic DevelopmentGene Expression Regulation, DevelopmentalGerm CellsHomeodomain ProteinsKidneyMiceMorphogenesisOrganogenesisProto-Oncogene ProteinsProto-Oncogene Proteins c-mdm2Tumor Suppressor Protein p53Axin2 protein, mouseAxin ProteinHomeodomain ProteinsHoxb7 protein, mouseMdm2 protein, mouseMdm4 protein, mouseProto-Oncogene ProteinsProto-Oncogene Proteins c-mdm2Trp53 protein, mouseTumor Suppressor Protein p53Wnt9b protein, mouseWnt Proteins

Identifiers

PMID32464196
PMCPMC7487065
OpenAlexW3029650918

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.