Evidence map›Paper›PMID 32463976›Full record

ArticleObesity (Silver Spring, Md.)2020

Circadian Rhythm of Substrate Oxidation and Hormonal Regulators of Energy Balance.

Corey A Rynders, Sarah J Morton, Daniel H Bessesen, Kenneth P Wright, Josiane L Broussard

Abstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Observational
  6. Review
  7. Review
  8. Article
  9. Article
  10. Circadian rhythms and gastrointestinal hormone-related appetite regulation.Current opinion in endocrinology, diabetes, and obesity · 2025
    Review
  11. Article
  12. Article
  13. Independent effects of the human circadian system and sleep/eating cycles on caloric intake in adolescents vary by weight status.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Corey A RyndersDivision of Geriatric Medicine, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0001-5767-6261
Sarah J MortonDepartment of Health and Exercise Science, Colorado State University, Fort Collins, Colorado, USA.
Daniel H BessesenDivision of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
Kenneth P WrightDivision of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
Josiane L BroussardCenter for Women's Health Research, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3M
NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
Time-restricted feeding to mitigate metabolic impairments during circadian misalignmentR01DK125653 · NIDDK · COLORADO STATE UNIVERSITY · PI BROUSSARD, JOSIANE · 2020 to 2024
$3.3M
POST-PRANDIAL NUTRIENT PARTITIONING IN HUMANSK24DK002935 · NIDDK · DENVER HEALTH AND HOSPITAL AUTHORITY · PI BESSESEN, DANIEL HOLLAND · 2001 to 2010
$1.5M
The Effects of Overfeeding on OP and OR WomenR01DK062874 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BESSESEN, DANIEL HOLLAND · 2003 to 2007
$1.1M
Time restricted feeding and metabolic rhythms in humansK01DK113063 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI RYNDERS, COREY ALLAN · 2017 to 2021
$832k
Effects of physical activity on cardiometabolic impairments associated with insufficient sleepK01DK110138 · NIDDK · UNIVERSITY OF COLORADO · PI BROUSSARD, JOSIANE · 2016 to 2018
$484k
Impact of insufficient sleep on peripheral metabolic tissuesR03DK118309 · NIDDK · COLORADO STATE UNIVERSITY · PI BROUSSARD, JOSIANE · 2018 to 2019
$170k
NCATS NIH HHS UL1 TR002535NCRR NIH HHS UL1 RR025780NIDDK NIH HHS K01 DK110138NIDDK NIH HHS K01 DK113063NIDDK NIH HHS K24 DK002935NIDDK NIH HHS P30 DK048520NIDDK NIH HHS R01 DK062874NIDDK NIH HHS R01 DK125653NIDDK NIH HHS R03 DK118309
6 · The paper itself

Abstract

objectiveThe circadian system provides an organism with the ability to anticipate daily food availability and appropriately coordinate metabolic responses. Few studies have simultaneously assessed factors involved in both the anticipation of energy availability (i.e., hormones involved in appetite regulation) and subsequent metabolic responses (such as energy expenditure and substrate oxidation) under conditions designed to reveal circadian rhythmicity.

methodsEight healthy adults (four females; age: 28.0 ± 2.3 years; BMI: 24.3 ± 2.9 kg/m

resultsFat and carbohydrate oxidation was highest in the biological evening and morning, respectively. Subjective hunger ratings peaked during the middle of the biological day. Significant circadian rhythms were identified for ghrelin and peptide YY with peaks in the biological evening and morning, respectively.

conclusionsThese findings support a role for the circadian system in the modulation of nutrient oxidation, subjective measures of appetite, and appetitive hormones.

Indexed as

Circadian RhythmEnergy MetabolismFemaleHumansMaleMiddle AgedOxidation-Reduction

Identifiers

PMID32463976
PMCPMC7381359

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.