ArticlePLoS pathogens2020
Host cytosolic RNA sensing pathway promotes T Lymphocyte-mediated mycobacterial killing in macrophages.
Article in PLoS pathogens, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Deferoxamine Exhibits Antimicrobial and Immunomodulatory Activity AgainstInternational journal of molecular sciences · 2026Article
- Host Cell-Derived Extracellular Vesicles Regulate Iron Uptake in Recipient Macrophages duringJournal of proteome research · 2025Article
- Microvesicles Derived from Human Bronchial Epithelial Cells Regulate Macrophage Activation DuringJournal of proteome research · 2025Article
- Characterization of Exosomes Released from Mycobacterium abscessus-Infected Macrophages.Proteomics · 2025Article
- ETS Transcription Factors in Immune Cells and Immune-Related Diseases.International journal of molecular sciences · 2024Review
- Mycobacterium abscessus extracellular vesicles increase mycobacterial resistance to clarithromycin in vitro.Proteomics · 2024Article
- Intracellular iron accumulation facilitates mycobacterial infection in old mouse macrophages.GeroScience · 2024Article
- Activation of host nucleic acid sensors byCritical reviews in microbiology · 2024Review
- Engineering a dual vaccine against COVID-19 and tuberculosis.Frontiers in cellular and infection microbiology · 2023Article
- Modulating macrophage function to reinforce host innate resistance againstFrontiers in immunology · 2022Review
- Profiling the mRNA and miRNA in Peripheral Blood Mononuclear Cells in Subjects with Active Tuberculosis.Infection and drug resistance · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Mycobacterial infection leads to activation of the RIG-I/MAVS/TBK1 RNA sensing pathway in macrophages but the consequences of this activation remains poorly defined. In this study, we determined that activation of this RNA sensing pathway stimulates ICAM-1 expression in M.avium-infected macrophage through the inhibition of the E3 ubiquitin ligase CRL4COP1/DET1. CRL4 when active targets the transcription factor ETV5 for degradation by the ubiquitin-proteasome system. In the absence of the ETV5 transcription factor, ICAM-1 expression is significantly decreased. The M.avium-induced ICAM-1 production is required for the formation of immune synapse between infected macrophages and antigen-specific CD4+ T lymphocytes, and is essential for CD4+ T lymphocyte-mediated mycobacterial killing in vitro and in mice. This study demonstrates a previously undefined mechanism by which a host cytosolic RNA sensing pathway contributes to the interplay between mycobacteria infected macrophages and antigen-specific T lymphocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.