Evidence map›Paper›PMID 32463725›Full record

ArticleAmerican journal of physiology. Renal physiology2020

14-3-3γ, a novel regulator of the large-conductance Ca

Shan Chen, Xiuyan Feng, Xinxin Chen, Zhizhi Zhuang, Jia Xiao, Haian Fu, Janet D Klein, Xiaonan H Wang, Robert S Hoover, Douglas C Eaton and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Shan ChenRenal Divison, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Xiuyan FengRenal Divison, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Xinxin ChenRenal Divison, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Zhizhi ZhuangRenal Divison, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Jia XiaoRenal Divison, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Haian FuDepartment of Pharmacology, Emory University, School of Medicine, Atlanta, Georgia.
Janet D KleinRenal Divison, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.ORCID 0000-0001-6663-1129
Xiaonan H WangRenal Divison, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.ORCID 0000-0002-1023-8499
Robert S HooverRenal Divison, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Douglas C EatonPhysiology, Emory University, School of Medicine, Atlanta, Georgia.
Hui CaiRenal Divison, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Emory University · USUnited States Department of Veterans Affairs · USUnion Hospital · CN

Funding

MicroRNA and Muscle Wasting in UremiaR01AR060268 · NIAMS · EMORY UNIVERSITY · PI WANG, XIAONAN H · 2012 to 2016
$1.7M
Mechanisms of Hormonal Regulation of the Sodium Chloride CotransporterR01DK085097 · NIDDK · EMORY UNIVERSITY · PI HOOVER, ROBERT S · 2010 to 2015
$1.5M
Regulation of Sodium Transport in Tight EpitheliaR01DK110409 · NIDDK · EMORY UNIVERSITY · PI EATON, DOUGLAS C. · 2018 to 2021
$1.4M
BLRD VA I01 BX000994BLRD VA I01 BX002322NIAMS NIH HHS R01 AR060268NIDDK NIH HHS R01 DK110409NIH NIAMS R01-AR-060268NIH NIDDK R01-085097NIH NIDDK R01-110409U.S. Department of Veterans Affairs (VA) VA Merit Award BX000994U.S. Department of Veterans Affairs (VA) VA Merit Award BX002322
6 · The paper itself

Abstract

14-3-3γ is a small protein regulating its target proteins through binding to phosphorylated serine/threonine residues. Sequence analysis of large-conductance Ca

Indexed as

14-3-3 ProteinsAnimalsButadienesChlorocebus aethiopsCOS CellsEnzyme InhibitorsHEK293 CellsHumansKidneyLarge-Conductance Calcium-Activated Potassium ChannelsLysosomesMacrolidesNitrilesPhosphorylationSignal Transduction14-3-3 Proteinsbafilomycin A1ButadienesEnzyme InhibitorsLarge-Conductance Calcium-Activated Potassium ChannelsMacrolidesNitrilesU 012614-3-3γextracellular signal-regulated kinase 1/2 signalinglarge-conductance Ca2+-activated K+ channelubiquitination

Identifiers

PMID32463725
PMCPMC7468830
OpenAlexW3030640360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.