Evidence map›Paper›PMID 32463679›Full record

ArticleNano letters2020

Untethered Single Cell Grippers for Active Biopsy.

Qianru Jin, Yuqian Yang, Julian A Jackson, ChangKyu Yoon, David H Gracias

Open access · greenAbstract read
In one paragraph

Article in Nano letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 87 citations in OpenAlex.

  1. Review
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  10. Towards multifunctional robotic pills.Nature biomedical engineering · 2024
    Review
  11. Article
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  13. Article
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  15. Article
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  18. Medical micro- and nanomotors in the body.Acta pharmaceutica Sinica. B · 2023
    Review
  19. Smart Magnetic Microrobots Learn to Swim with Deep Reinforcement Learning.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Qianru JinDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.ORCID 0000-0003-3182-8188
Yuqian YangDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.ORCID 0000-0002-2510-9788
Julian A JacksonDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.ORCID 0000-0002-0182-4904
ChangKyu YoonDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.ORCID 0000-0003-3716-4853
David H GraciasDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.ORCID 0000-0003-2735-4725
Johns Hopkins University · US

Funding

Tissue biopsying with wireless microgrippers within gastrointestinal tractR01EB017742 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI David H Gracias, Florin Selaru · 2014 to 2026
$6.6M
NIBIB NIH HHS R01 EB017742
6 · The paper itself

Abstract

Single cell manipulation is important in biosensing, biorobotics, and quantitative cell analysis. Although microbeads, droplets, and microrobots have been developed previously, it is still challenging to simultaneously excise, capture, and manipulate single cells in a biocompatible manner. Here, we describe untethered single cell grippers, that can be remotely guided and actuated on-demand to actively capture or excise individual or few cells. We describe a novel molding method to micropattern a thermally responsive wax layer for biocompatible motion actuation. The multifingered grippers derive their energy from the triggered release of residual differential stress in bilayer hinges composed of silicon oxides. A magnetic layer enables remote guidance through narrow conduits and fixed tissue sections

Indexed as

RoboticsBiopsyMagneticsMotionSilicon DioxideSilicon Dioxidebiomedical engineeringdrug deliverygenomicsmoldingproteomicsroboticstissue sampling

Identifiers

PMID32463679
PMCPMC7405256
OpenAlexW3030989713

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.