ArticleHuman brain mapping2022
Translating ENIGMA schizophrenia findings using the regional vulnerability index: Association with cognition, symptoms, and disease trajectory.
Abstract readMulticenter Study
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Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.
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37citing papers in PubMed, 4 pooled it
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Who cites it
37 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Ancestral, Pregnancy, and Negative Early-Life Risks Shape Children's Brain (Dis)similarity to Schizophrenia.Biological psychiatry · 2023Pooled it
- Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11.2 deletion syndrome: A review of ENIGMA findings.Psychiatry and clinical neurosciences · 2022Pooled it
- Morphometric Analysis of Structural MRI Using Schizophrenia Meta-analytic Priors Distinguish Patients from Controls in Two Independent Samples and in a Sample of Individuals With High Polygenic Risk.Schizophrenia bulletin · 2022Pooled it
- Separating Clinical and Subclinical Depression by Big Data Informed Structural Vulnerability Index and Its impact on Cognition: ENIGMA Dot Product.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2022Pooled it
- Multiscale characterization of cortical signatures in positive and negative schizotypy: a worldwide ENIGMA study.Molecular psychiatry · 2026Article
- Family-Level Brain Pattern Similarities and Their Clinical Significance in Young Offspring of Individuals With Psychotic Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Altered frontal and occipital cortical microstructure in obsessive-compulsive disorder - a multisite mega-analysis.Molecular psychiatry · 2026Article
- Neuroimaging Summary Scores Predict Trajectories of Psychotic-Like Experiences in Youth.medRxiv : the preprint server for health sciences · 2026Article
- Brainwide Structural Markers of Familial and Clinical Risk for Bipolar Disorder in Youth.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Mapping Multimodal Risk Factors to Mental Health Outcomes.Nature. Mental health · 2025Article
- Functional vs Structural Cortical Deficit Pattern Biomarkers for Major Depressive Disorder.JAMA psychiatry · 2025Article
- Distinct cognitive trajectories in the early course of psychosis are associated with clinical and functional outcomes longitudinally.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Identification of Factors to Predict Transition to Schizophrenia in Subjects with Ultra-high Risk for Psychosis: A Protocol for a Multicenter, Longitudinal Study of Sleep Parameters and Cytokine Levels.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- Advancing treatment response prediction in first-episode psychosis: integrating clinical and electroencephalography features.Psychiatry and clinical neurosciences · 2025Article
- White matter and latency of visual evoked potentials during maturation: A miniature pig model of adolescent development.Journal of neuroscience methods · 2024Article
- Multimodal Neuroimaging Summary Scores as Neurobiological Markers of Psychosis.Schizophrenia bulletin · 2024Article
- Psychosis superspectrum II: neurobiology, treatment, and implications.Molecular psychiatry · 2024Review
- Cumulative Effects of Resting-State Connectivity Across All Brain Networks Significantly Correlate with Attention-Deficit Hyperactivity Disorder Symptoms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cortical Network Disruption Is Minimal in Early Stages of Psychosis.Schizophrenia bulletin open · 2024Article
- Comparison of deep learning architectures for predicting amyloid positivity in Alzheimer's disease, mild cognitive impairment, and healthy aging, from T1-weighted brain structural MRI.Frontiers in neuroscience · 2024Article
Corrections and comments
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Authors and funding
22 authors.
Peter KochunovMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-3656-4281
Fengmei FanBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, People's Republic of China.ORCID 0000-0003-1028-6754
Meghann C RyanMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Kathryn S HatchMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Shuping TanBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, People's Republic of China.
Neda JahanshadImaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Los Angeles, California, USA.
Paul M ThompsonImaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, Los Angeles, California, USA.
Theo G M van ErpDepartment of Psychiatry, University of California Irvine, Irvine, California, USA.
Jessica A TurnerDepartment of Psychology and Neuroscience Institute, Georgia State University, Atlanta, Georgia, USA.
Shuo ChenMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-7990-4947
Xiaoming DuMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Bhim AdhikariMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Heather BruceMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Stephanie HareMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Eric GoldwaserMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Mark KvartaMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Junchao HuangBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, People's Republic of China.
Jinghui TongBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, People's Republic of China.
Yimin CuiDepartment of Pharmacy, Peking University First Hospital, Beijing, China.
Baopeng CaoBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, People's Republic of China.
Yunlong TanBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, People's Republic of China.
L Elliot HongMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Funding
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2012 to 2022
$14.1MSOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0MENIGMA-COINSTAC-APOE2 Functional and structural connectome protective mechanisms for Alzheimer’s disease and mood disorders: Request for supplemental funds for NIH R01:1R01MH121246R01MH121246 · NIMH · OHIO STATE UNIVERSITY · PI CALHOUN, VINCE D, TURNER, JESS · 2019 to 2023
$5.0MAmish Connectome Project on Mental IllnessU01MH108148 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT, KOCHUNOV, PETER V. · 2015 to 2018
$4.3MTowards Multisystem-Brain Successful Aging in Schizophrenia SpectrumR01MH116948 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HONG, L ELLIOT ELLIOT · 2018 to 2022
$3.7MA Multivariate Mediation and Deep Learning Framework for Genome-Connectome -Substance Use ResearchDP1DA048968 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI CHEN, SHUO · 2019 to 2023
$2.3MThe Vascular Axis in Schizophrenia Brain-Body AgingR01MH133812 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI L Elliot Elliot Hong · 2024 to 2026
$2.2MRedefine Trans-Neuropsychiatric Disorder Brain Patterns through Big-Data and Machine LearningRF1MH123163 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V., THOMPSON, PAUL M · 2021 to 2021
$1.2MThe Role of Stress-Immune-Connectome Disruption in Mechanisms of Chinese Early Schizophrenia SpectrumR01MH112180 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT · 2017 to 2021
$1.0MHybrid GPU/CPU Computing Resource to Support Connectomic and GenomicsS10OD023696 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V. · 2018 to 2018
$593kNIBIB NIH HHS P41 EB015922NIBIB NIH HHS R01 EB015611NIDA NIH HHS DP1 DA048968NIH HHS R01EB015611NIH HHS R01MH112180NIH HHS R01MH116948NIH HHS S10 OD023696NIH HHS S10OD023696NIH HHS U01MH108148NIMH NIH HHS R01 MH112180NIMH NIH HHS R01 MH116948NIMH NIH HHS R01 MH121246NIMH NIH HHS R01 MH133812NIMH NIH HHS RF1 MH123163NIMH NIH HHS U01 MH108148
Abstract
Patients with schizophrenia have patterns of brain deficits including reduced cortical thickness, subcortical gray matter volumes, and cerebral white matter integrity. We proposed the regional vulnerability index (RVI) to translate the results of Enhancing Neuro Imaging Genetics Meta-Analysis studies to the individual level. We calculated RVIs for cortical, subcortical, and white matter measurements and a multimodality RVI. We evaluated RVI as a measure sensitive to schizophrenia-specific neuroanatomical deficits and symptoms and studied the timeline of deficit formations in: early (≤5 years since diagnosis, N = 45, age = 28.8 ± 8.5); intermediate (6-20 years, N = 30, age 43.3 ± 8.6); and chronic (21+ years, N = 44, age = 52.5 ± 5.2) patients and healthy controls (N = 76, age = 38.6 ± 12.4). All RVIs were significantly elevated in patients compared to controls, with the multimodal RVI showing the largest effect size, followed by cortical, white matter and subcortical RVIs (d = 1.57, 1.23, 1.09, and 0.61, all p < 10
Indexed as
Disease ProgressionMagnetic Resonance ImagingNeuroimagingAdolescentAdultAgedCerebral CortexChronic DiseaseCognitive DysfunctionDiffusion Tensor ImagingGray MatterHumansMiddle AgedSchizophreniaWhite MatterYoung AdultENIGMAgray matterregional vulnerability indexschizophreniawhite matter
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