ArticleeLife2020
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Screening the composition of tubulin isotypes reveals the most abundant TUBB4B for ciliary polarity in ependymal cells.Journal of molecular cell biology · 2026Article
- Adult-Onset Familial TUBB4A-Related Leukodystrophy Caused by c.286G>A (p.Gly96Arg) in a Korean Family: A Case Report.Journal of movement disorders · 2026Article
- STAT1 accelerates cutaneous melanoma progression through TUBB4A expression regulation.Molecular medicine reports · 2026Article
- CSF1R T567M mutation induces microglial dysfunction and synaptic impairment in patient iPSC-derived cerebral organoids of CSF1R-related disorder.Cell death discovery · 2026Article
- A scoping review of stem cell models of leukodystrophies: advances in understanding pathophysiological mechanisms.NPJ genomic medicine · 2025Article
- TUBB4A relieves high glucose-induced cardiomyocyte hypertrophy and apoptosis through the regulation of ubiquitination and activation of the NOTCH signaling pathway.Cytotechnology · 2025Article
- Revealing the Transcriptional and Metabolic Characteristics of Sebocytes Based on the Donkey Cell Transcriptome Atlas.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Effective gene therapy for metachromatic leukodystrophy achieved with minimal lentiviral genomic integrations.Molecular therapy. Nucleic acids · 2025Article
- TUBB4A Inhibits Glioma Development by Regulating ROS-PINK1/Parkin-Mitophagy Pathway.Molecular neurobiology · 2025Article
- Article
- In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration.Scientific reports · 2023Article
- H-ABC tubulinopathy revealed by label-free second harmonic generation microscopy.Scientific reports · 2022Article
- H-ABC- and dystonia-causingScience advances · 2022Article
- Oligodendrocyte and Extracellular Matrix Contributions to Central Nervous System Motor Function: Implications for Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2022Review
- A dominant tubulin mutation causes cerebellar neurodegeneration in a genetic model of tubulinopathy.Science advances · 2022Article
- Emerging cellular themes in leukodystrophies.Frontiers in cell and developmental biology · 2022Review
- Secreted Amyloid Precursor Protein Alpha, a Neuroprotective Protein in the Brain Has Widespread Effects on the Transcriptome and Proteome of Human Inducible Pluripotent Stem Cell-Derived Glutamatergic Neurons Related to Memory Mechanisms.Frontiers in neuroscience · 2022Article
- Hypomyelinating leukodystrophies - unravelling myelin biology.Nature reviews. Neurology · 2021Review
- Emerging Concepts in Vector Development for Glial Gene Therapy: Implications for Leukodystrophies.Frontiers in cellular neuroscience · 2021Review
- Microtubule Dysfunction: A Common Feature of Neurodegenerative Diseases.International journal of molecular sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 1 country.
Sunetra Sase *Department of Neurology, The Children's Hospital of Philadelphia, Philadelphia, United States.
Akshata A Almad *Department of Neurology, The Children's Hospital of Philadelphia, Philadelphia, United States.ORCID 0000-0001-6603-2564
C Alexander BoeckerDepartment of Physiology, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Pedro Guedes-DiasDepartment of Physiology, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Jian J LiDepartment of Neurology, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Asako TakanohashiDepartment of Neurology, The Children's Hospital of Philadelphia, Philadelphia, United States.
Akshilkumar PatelDepartment of Neurology, The Children's Hospital of Philadelphia, Philadelphia, United States.
Tara McCaffreyDepartment of Neurology, The Children's Hospital of Philadelphia, Philadelphia, United States.
Heta PatelDepartment of Neurology, The Children's Hospital of Philadelphia, Philadelphia, United States.
Divya SirdeshpandeDepartment of Neurology, The Children's Hospital of Philadelphia, Philadelphia, United States.
Julian CurielDepartment of Neurology, The Children's Hospital of Philadelphia, Philadelphia, United States.
Judy Shih-Hwa LiuDepartment of Neurology, Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, United States.
Quasar PadiathDepartment of Human Genetics and Neurobiology, University of Pittsburgh, Pittsburgh, United States.
Erika Lf HolzbaurDepartment of Physiology, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0001-5389-4114
Steven S SchererDepartment of Neurology, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Adeline VanderverDepartment of Neurology, The Children's Hospital of Philadelphia, Philadelphia, United States.ORCID 0000-0002-6290-6751
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · USBrown University · USUniversity of Pittsburgh · US
Funding
The Intellectual and Developmental Disabilities Research Center at CHOP/PennU54HD086984 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI YUDKOFF, MARC · 2016 to 2020
$6.3MMolecular Mechanisms of Axonal Transport and Organelle DynamicsR35GM126950 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Erika L Holzbaur · 2018 to 2026
$5.6MMechanistic analysis of axonal transport defects in neurodegenerative diseaseR37NS060698 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI HOLZBAUR, ERIKA L · 2014 to 2020
$2.9MElucidating mechanisms involved in Lamin B1 mediated demyelinationR01NS095884 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PADIATH, QUASAR S · 2016 to 2020
$2.1MHigh-content screening for modulators of lamin B1 as a therapeutic target in autosomal dominant leukodystrophyR33NS106087 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PADIATH, QUASAR S, VOGT, ANDREAS · 2019 to 2020
$783kExploring Antisense Oligonucleotides as a potential therapy for Autosomal Dominant LeukodystrophyR33NS104384 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PADIATH, QUASAR S · 2020 to 2021
$748kStudying the role of the nuclear lamina in age dependent demyelinationR21AG046897 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PADIATH, QUASAR S · 2013 to 2014
$434kHigh-content screening for modulators of lamin B1 as a therapeutic target in autosomal dominant leukodystrophyR21NS106087 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PADIATH, QUASAR S, VOGT, ANDREAS · 2018 to 2018
$391kExploring Antisense Oligonucleotides as a potential therapy for Autosomal Dominant LeukodystrophyR21NS104384 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PADIATH, QUASAR S · 2018 to 2018
$353kNIA NIH HHS R21 AG046897NICHD NIH HHS U54 HD086984NIGMS NIH HHS R35 GM126950NIH HHS R35 GM126950NIH HHS R37 NS060698NINDS NIH HHS R01 NS095884NINDS NIH HHS R21 NS104384NINDS NIH HHS R21 NS106087NINDS NIH HHS R33 NS104384NINDS NIH HHS R33 NS106087NINDS NIH HHS R37 NS060698
Abstract
Mutations in
Indexed as
Disease Models, AnimalHereditary Central Nervous System Demyelinating DiseasesAnimalsBasal GangliaCerebellumGene Knock-In TechniquesMiceMice, TransgenicMutationNeuronsOligodendrogliaTubulinTUBB4A protein, mouseTubulinhypomyelinationleukodystrophymicrotubulemouseneurodegenerationneuroscienceTUBB4A
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.