Evidence map›Paper›PMID 32463335›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2020

Alterations in pancreatic islet cell function in response to small bowel resection.

Cathleen M Courtney, Zeenat A Shyr, Zihan Yan, Emily Jean Onufer, Allie E Steinberger, Maria E Tecos, Lauren K Barron, Jun Guo, Maria S Remedi, Brad W Warner

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Cathleen M CourtneyDivision of Pediatric Surgery, Department of Surgery, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri.
Zeenat A ShyrDivision of Endocrinology, Metabolism, and Lipid Research, Washington University in St. Louis, Missouri.
Zihan YanDivision of Endocrinology, Metabolism, and Lipid Research, Washington University in St. Louis, Missouri.
Emily Jean OnuferDivision of Pediatric Surgery, Department of Surgery, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri.
Allie E SteinbergerDivision of Pediatric Surgery, Department of Surgery, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri.
Maria E TecosDivision of Pediatric Surgery, Department of Surgery, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri.
Lauren K BarronDivision of Pediatric Surgery, Department of Surgery, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri.
Jun GuoDivision of Pediatric Surgery, Department of Surgery, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri.
Maria S RemediDivision of Endocrinology, Metabolism, and Lipid Research, Washington University in St. Louis, Missouri.ORCID 0000-0003-2048-472X
Brad W WarnerDivision of Pediatric Surgery, Department of Surgery, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri.
St. Louis Children's Hospital · USWashington University in St. Louis · US

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1M
ANGIOGENESIS IN INTESTINAL ADAPTATIONR01DK104698 · NIDDK · WASHINGTON UNIVERSITY · PI WARNER, BRAD WAYNE · 2015 to 2018
$1.4M
Bile acid metabolomics and metagenomics in short bowel syndromeR01DK112378 · NIDDK · WASHINGTON UNIVERSITY · PI DAVIDSON, NICHOLAS O., RUBIN, DEBORAH C. · 2016 to 2018
$1.1M
NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK104698NIDDK NIH HHS R01 DK112378
6 · The paper itself

Abstract

After 50% proximal small bowel resection (SBR) in mice, we have demonstrated hepatic steatosis, impaired glucose metabolism without insulin resistance, and increased pancreatic islet area. We sought to determine the consequences of SBR on pancreatic β-cell morphology, proliferation, and expression of a key regulatory hormone, glucagon-like peptide-1 (GLP-1). C57BL/6 mice underwent 50% SBR or sham operation. At 10 wk, pancreatic insulin content and secretion was measured by ELISA. Immunohistochemistry was performed to determine structural alterations in pancreatic α-and β-cells. Western blot analysis was used to measure

Indexed as

AnimalsGlucagonGlucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorInsulinInsulin-Secreting CellsIntestinesIslets of LangerhansMice, Inbred C57BLPancreasPancreas, ExocrineGlucagonGlucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorInsulinglucagon-like protein 1 receptorpancreassmall bowel resection

Identifiers

PMID32463335
PMCPMC7468758
OpenAlexW3031340253

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.