ArticleJournal of abnormal psychology2020
Evidence for two genetically distinct pathways to co-occurring internalizing and externalizing problems in adolescence characterized by negative affectivity or behavioral inhibition.
Article in Journal of abnormal psychology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genetics of child aggression, a systematic review.Translational psychiatry · 2024Pooled it
- A Developmentally Informed Systematic Review and Meta-Analysis of the Strength of General Psychopathology in Childhood and Adolescence.Clinical child and family psychology review · 2024Pooled it
- The role of early intervention for adolescent mental health and polydrug use: Cascading mediation through childhood growth in the general psychopathology (p) factor.Developmental psychology · 2023Trial
- The association between temperament and polygenic score for psychopathology from infancy to middle childhood.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Acculturative stress among Latino youth: A bioecological framework.Advances in psychiatry and behavioral health · 2024Article
- An examination of the relationship between conduct problems and depressive symptoms comorbidity and temperament among elementary school children.Child psychiatry and human development · 2024Article
- Polygenic risk for aggressive behavior from late childhood through early adulthood.European child & adolescent psychiatry · 2023Article
- Longitudinal relationship between depression and antisocial behaviors in Korean adolescents.Frontiers in psychiatry · 2023Article
- Birth Complications and Negative Emotionality Predict Externalizing Behaviors in Young Twins: Moderations with Genetic and Family Risk Factors.Behavior genetics · 2021Article
- Prediction Along a Developmental Perspective in Psychiatry: How Far Might We Go?Frontiers in systems neuroscience · 2021Review
- Emotion dysregulation as a pathway linking adversity and temperament to general psychopathology in childhood.International journal of clinical and health psychology : IJCHPArticle
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5 authors.
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Abstract
Unique pathways to adolescents' co-occurring internalizing/externalizing problems, a severe and common form of psychopathology, remain poorly delineated; this paucity of knowledge impedes the development of personalized interventions. We examined established measures of genetic risk and early childhood temperamental dimensions to clarify potentially distinct pathways to adolescents' co-occurring internalizing/externalizing problems. Participants were drawn from a longitudinal randomized controlled trial of a family-based intervention. The study employed multiple informants and methods, including observer ratings of toddlers' negative affectivity and behavioral inhibition, and primary caregiver ratings of toddlers' inhibitory control; internalizing and aggression polygenic risk scores (PRS) based on prior meta-genome-wide association studies (GWAS); and parents' and teachers' reports of adolescents' internalizing and externalizing problems. Higher levels of the aggression PRS indirectly predicted primary caregiver- and teacher-reported co-occurring problems relative to all other groups through greater early childhood negative affectivity. Lower levels of the aggression PRS and higher levels of the internalizing PRS indirectly predicted co-occurring problems relative to the externalizing "only" and low problem groups (primary caregivers only) through greater early childhood behavioral inhibition. Findings suggest two different genetic pathways to co-occurring problems that could lead to distinct prevention and intervention efforts. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
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