Evidence map›Paper›PMID 32463180›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2020

The Banff 2019 Kidney Meeting Report (I): Updates on and clarification of criteria for T cell- and antibody-mediated rejection.

Alexandre Loupy, Mark Haas, Candice Roufosse, Maarten Naesens, Benjamin Adam, Marjan Afrouzian, Enver Akalin, Nada Alachkar, Serena Bagnasco, Jan U Becker and 35 more

9 registry-linked trialsAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 9 registered trials, which are not on this map. Cited by 455 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
455citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04936282 phase4unknown statusnot on this mapstarted 2022, after this paper: background citation

Treatment of Early Borderline Lesions in Low Immunological Risk Kidney Transplant Patients: a Spanish Multicenter, Randomized, Controlled Parallel-group Trial: The TRAINING Study

TypeinterventionalSponsorFundación Canaria Instituto de Investigación Sanitaria de CanariasRan2022 to 2024Enrolled80ConditionsKidney Transplant Failure and RejectionArmsGrafalon, Normal Treatment
NCT05306795 unknown statusnot on this map

Development, Application, and Validation of a Comprehensive Classification Automation System for Allograft Precision Diagnostics in Adult and Pediatric Kidney Transplant Biopsies

TypeobservationalSponsorParis Translational Research Center for Organ TransplantationRan2016 to 2022Enrolled4,000ConditionsKidney Transplant Rejection, Pathology
NCT05335538 unknown statusnot on this mapstarted 2021, after this paper: background citation

The Role of TruGraf® to Optimize Outcomes in Pediatric Renal Transplantation

TypeobservationalSponsorTransplant Genomics, Inc.Ran2021 to 2023Enrolled75ConditionsKidney Transplant RejectionArmsPatients monitored with TruGraf and TRAC testing
NCT05635136 completednot on this mapstarted 2022, after this paper: background citation

Histopathological Analysis of Renal Biopsies With Dynamic Full-field Optical Coherence Tomography, a Comparison to Conventional Histopathological Findings in Kidney Transplant Recipients

Typeobservational_patient_registrySponsorCentre Hospitalier William Morey - Chalon sur SaôneRan2022 to 2023Enrolled16ConditionsTomography, Optical Coherence, Kidney TransplantationArmsDynamic full-field optical coherence tomography analysis of kidney transplant biopsy
NCT05753930 phase2recruitingnot on this mapstarted 2023, after this paper: background citation

A Single-arm, Multi-centre Trial to Evaluate Efficacy and Safety of Imlifidase in Highly Sensitised Children (1-17 Years) Receiving a Kidney Transplant With Positive Crossmatch Against a Living or Deceased Donor Converted to Negative After Imlifidase Treatment

TypeinterventionalSponsorHansa Biopharma ABRan2023 to 2031Enrolled10ConditionsKidney Transplantation in Highly Sensitized PatientsArmsImlifidase
NCT06342128 recruitingnot on this mapstarted 2022, after this paper: background citation

Comprehensive Multiscale Characterization of the Molecular Landscape of Microvascular Inflammation in Kidney Allografts

TypeobservationalSponsorParis Translational Research Center for Organ TransplantationRan2022 to 2025Enrolled600ConditionsKidney Rejection TransplantArmsNo intervention
NCT07231328 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Post-Transplant Application of TruGraf and TRAC Molecular Panel in Renal Transplant Recipients

TypeobservationalSponsorTransplant Genomics, Inc.Ran2025 to 2029Enrolled600ConditionsImmunosuppression Management, Biomarkers / Blood, Subclinical Rejection, BiopsyArmsThere is no required Intervention for this Protocol. Based on Results for TruGraf/TRAC/TRAC ID Investigators may use the results in managing subjects Immunosuppression or rule out rejection.
NCT07393594 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Prospective, Multicenter, Observational Study Evaluating Serial T-ID Monitoring for the Prevention of CMV Disease and BK Virus-Associated Nephropathy Following Kidney Transplantation

TypeobservationalSponsorTransplant Genomics, Inc.Ran2026 to 2028Enrolled1,000ConditionsKidney Diseases, Kidney Injury, BK Virus Infection, CMVArmsBlood tests, TRAC( cell free DNA) and T-ID
NCT07689578 phase4recruitingnot on this mapstarted 2026, after this paper: background citation

Safety and Efficacy of the Bispecific T-Cell Engager (BiTE) in Kidney Transplant Recipients With Chronic Active Antibody-Mediated Rejection

TypeinterventionalSponsorTurun SongRan2026 to 2029Enrolled50ConditionsAntibody Mediated Rejection After Kidney TransplantationArmsBiTE (BCMA x CD3 Bispecific Antibody)
3 · Its place in the literature

Who cites it

455 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Guideline
  2. International Society for Heart and Lung Transplantation Scientific Statement on pulmonary antibody-mediated rejection and proposed graft, antibody, and pathology (GAP) definition.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026
    Guideline
  3. Pooled it
  4. Pooled it
  5. Immunosuppression in Older Kidney Transplant Recipients: A Randomized Controlled Trial.Journal of the American Society of Nephrology : JASN · 2026
    Trial
  6. Trial
  7. Donor-derived cell-free DNA monitoring for early diagnosis of antibody-mediated rejection after kidney transplantation: a randomized trial.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Trial
  8. Trial
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Tailoring HLA antibody monitoring post-transplantation.Pediatric nephrology (Berlin, Germany) · 2026
    Article
  16. First Experience with [Diagnostics (Basel, Switzerland) · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Article

395 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors.

Alexandre LoupyUniversité de Paris, INSERM U970, University of Paris, Paris Translational Research Centre for Organ Transplantation, Paris and Necker Hospital, Assistance Publique - Hopitaux de Paris, Paris, France.ORCID 0000-0003-3388-7747
Mark HaasDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Candice RoufosseDepartment of Immunology and Inflammation, Imperial College London and North West London Pathology, London, UK.ORCID 0000-0002-6490-4290
Maarten NaesensDepartment of Microbiology and Immunology, University of Leuven, Leuven, Belgium.
Benjamin AdamDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada.ORCID 0000-0003-1908-1739
Marjan AfrouzianDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Enver AkalinMontefiore-Einstein Center for Transplantation, Montefiore Medical Center, Bronx, New York, USA.
Nada AlachkarDepartment of Medicine, Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Serena BagnascoDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jan U BeckerInstitute of Pathology, University Hospital of Cologne, Cologne, Germany.
Lynn D CornellDivision of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Marian C Clahsen-van GroningenDepartment of Pathology, Erasmus MC, Rotterdam, the Netherlands.ORCID 0000-0003-0565-9560
Anthony J DemetrisDepartment of Pathology, The Thomas E Starzl Transplantation Institute, University of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-9582-3733
Duska DragunDepartment of Nephrology and Critical Care Medicine, Berlin Institute of Health, Charite Universitätsmedizin, Berlin, Germany.
Jean-Paul Duong van HuyenUniversité de Paris, INSERM U970, University of Paris, Paris Translational Research Centre for Organ Transplantation, Paris and Necker Hospital, Assistance Publique - Hopitaux de Paris, Paris, France.ORCID 0000-0002-3051-2141
Alton B FarrisEmory University, Atlanta, Georgia, USA.ORCID 0000-0001-5534-7763
Agnes B FogoDepartments of Pathology, Microbiology, and Immunology; Medicine and Pediatrics, Vanderbilt University, Nashville, Tennessee, USA.
Ian W GibsonDepartment of Pathology, University of Manitoba, Winnipeg, Canada.
Denis GlotzParis Translational Research Center for Organ Transplantation, Department of Nephrology and Transplantation, Hopital Saint Louis, Université Paris VII, INSERM U 1160, Paris, France.
Juliette GueguenUniversité de Paris, INSERM U970, University of Paris, Paris Translational Research Centre for Organ Transplantation, Paris and Necker Hospital, Assistance Publique - Hopitaux de Paris, Paris, France.
Zeljko KikicDepartments of Medicine and Pathology, Medical University of Vienna, Vienna, Austria.
Nicolas KozakowskiDepartments of Medicine and Pathology, Medical University of Vienna, Vienna, Austria.
Edward KrausDepartment of Medicine, Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Carmen LefaucheurParis Translational Research Center for Organ Transplantation, Department of Nephrology and Transplantation, Hopital Saint Louis, Université Paris VII, INSERM U 1160, Paris, France.
Helen LiapisDepartment of Pathology & Immunology & Internal Medicine (Renal) Retired, Washington University School of Medicine, Saint Louis, Missouri, USA.
Roslyn B MannonDivision of Nephrology, Department of Medicine, University of Alabama School of Medicine, Birmingham, Alabama, USA.ORCID 0000-0003-1776-3680
Robert A MontgomeryNew York University Langone Medical Center, NYU Langone Transplant Institute, New York, New York, USA.
Brian J NankivellDepartment of Renal Medicine, Westmead Hospital, Sydney, Australia.ORCID 0000-0002-2300-0287
Volker NickeleitDivision of Nephropathology, Department of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, North Carolina, USA.
Peter NickersonDepartment of Internal Medicine and Immunology, University of Manitoba, Winnipeg, Canada.ORCID 0000-0002-7393-7799
Marion RabantUniversité de Paris, INSERM U970, University of Paris, Paris Translational Research Centre for Organ Transplantation, Paris and Necker Hospital, Assistance Publique - Hopitaux de Paris, Paris, France.ORCID 0000-0001-5696-6478
Lorraine RacusenDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Parmjeet RandhawaDepartment of Pathology, The Thomas E Starzl Transplantation Institute, University of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-7523-3437
Blaise RobinUniversité de Paris, INSERM U970, University of Paris, Paris Translational Research Centre for Organ Transplantation, Paris and Necker Hospital, Assistance Publique - Hopitaux de Paris, Paris, France.
Ivy A RosalesDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Ruth Sapir-PichhadzeDivision of Experimental Medicine, Department of Medicine, McGill University, Montreal, Canada.
Carrie A SchinstockWilliam J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-3274-3277
Daniel SeronNephrology Department, Hospital Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain.
Harsharan K SinghDivision of Nephropathology, Department of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, North Carolina, USA.ORCID 0000-0002-3123-5027
Rex N SmithDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Mark D StegallDepartments of Surgery and Immunology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-9157-5405
Adriana ZeeviDepartment of Pathology, The Thomas E Starzl Transplantation Institute, University of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kim SolezDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada.
Robert B ColvinDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Michael MengelDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada.ORCID 0000-0002-7222-3356

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The XV. Banff conference for allograft pathology was held in conjunction with the annual meeting of the American Society for Histocompatibility and Immunogenetics in Pittsburgh, PA (USA) and focused on refining recent updates to the classification, advances from the Banff working groups, and standardization of molecular diagnostics. This report on kidney transplant pathology details clarifications and refinements to the criteria for chronic active (CA) T cell-mediated rejection (TCMR), borderline, and antibody-mediated rejection (ABMR). The main focus of kidney sessions was on how to address biopsies meeting criteria for CA TCMR plus borderline or acute TCMR. Recent studies on the clinical impact of borderline infiltrates were also presented to clarify whether the threshold for interstitial inflammation in diagnosis of borderline should be i0 or i1. Sessions on ABMR focused on biopsies showing microvascular inflammation in the absence of C4d staining or detectable donor-specific antibodies; the potential value of molecular diagnostics in such cases and recommendations for use of the latter in the setting of solid organ transplantation are presented in the accompanying meeting report. Finally, several speakers discussed the capabilities of artificial intelligence and the potential for use of machine learning algorithms in diagnosis and personalized therapeutics in solid organ transplantation.

Indexed as

Graft RejectionKidney TransplantationArtificial IntelligenceKidneyT-Lymphocytesclassification systems: Banff classificationclinical decision-makingclinical research/practicekidney (allograft) function/dysfunctionkidney transplantation/nephrologymolecular biology: mRNA/mRNA expressionpathology/histopathologyrejectiontranslational research/science

Identifiers

PMID32463180
PMCPMC7496245

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.