Evidence map›Paper›PMID 32463148›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2020

Cancer cells display increased migration and deformability in pace with metastatic progression.

Zhenhui Liu, Se Jong Lee, Seungman Park, Konstantinos Konstantopoulos, Kristine Glunde, Yun Chen, Ishan Barman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

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  15. Onco-Breastomics: An Eco-Evo-Devo Holistic Approach.International journal of molecular sciences · 2024
    Review
  16. Article
  17. Article
  18. WASP facilitates tumor mechanosensitivity in T lymphocytes.bioRxiv : the preprint server for biology · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhenhui LiuDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Se Jong LeeDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
Seungman ParkDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Konstantinos KonstantopoulosDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
Kristine GlundeThe Russell H. Morgan Department of Radiology and Radiological Science, Division of Cancer Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yun ChenDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Ishan BarmanDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.

Funding

Wide-Field Short-Wave Infrared (SWIR) multiphoton (MP) tissue imagingP41EB015871 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SO, PETER T. · 2012 to 2021
$11.3M
Translational Aging Research Training ProgramT32AG058527 · NIA · JOHNS HOPKINS UNIVERSITY · PI Peter M. Abadir, Esther Seunghee Oh · 2018 to 2026
$4.0M
Development of high throughput screening technologies in breast cancerR01CA183804 · NCI · JOHNS HOPKINS UNIVERSITY · PI KONSTANTOPOULOS, KONSTANTINOS, KONTROGIANNI-KONSTANTOPOULOS, AIKATERINI · 2015 to 2019
$3.5M
Spectroscopy assisted mechano-chemical phenotype recognition nanoscopeDP2GM128198 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BARMAN, ISHAN · 2017 to 2017
$2.5M
Hypoxia-derived molecular MSI signatures to predict breast cancer outcomeR01CA213492 · NCI · JOHNS HOPKINS UNIVERSITY · PI GLUNDE, KRISTINE, HEEREN, RON · 2017 to 2021
$2.1M
Molecular studies of the MR-detectable oncometabolite glycerophosphocholineR01CA213428 · NCI · JOHNS HOPKINS UNIVERSITY · PI GLUNDE, KRISTINE · 2017 to 2021
$1.9M
NCI NIH HHS R01 CA183804NCI NIH HHS R01 CA213428NCI NIH HHS R01 CA213492NIA NIH HHS T32 AG058527NIBIB NIH HHS P41 EB015871NIGMS NIH HHS DP2 GM128198
6 · The paper itself

Abstract

In this study, we explored the relation between metastatic states vs the capacity of confined migration, amoeboid transition, and cellular stiffness. We compared across an isogenic panel of human breast cancer cells derived from MDA-MB-231 cells. It was observed that cells after lung metastasis have the fastest migration and lowest stiffness, with a significantly higher capacity to transition into an amoeboid mode. Our findings illustrate that metastasis is a selective process favoring motile and softer cells. Moreover, the observation that circulating tumor cells resemble the parental cell line, but not lung-metastatic cells, suggests that cells with higher deformability and motility are likely selected during extravasation and colonization.

Indexed as

Cell MovementEpithelial-Mesenchymal TransitionApoptosisBreast NeoplasmsCell ProliferationDisease ProgressionFemaleHumansLung NeoplasmsNeoplasm MetastasisTumor Cells, Culturedamoeboid movementbreast cancer metastasisisogenic cell linesmechanotypingmicrochannel migration

Identifiers

PMID32463148
PMCPMC7547847

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.