Evidence map›Paper›PMID 32463112›Full record

ArticleThe Journal of physiology2020

Mechanisms underlying selective coupling of endothelial Ca

Matteo Ottolini, Zdravka Daneva, Yen-Lin Chen, Eric L Cope, Ramesh B Kasetti, Gulab S Zode, Swapnil K Sonkusare

Open access · greenAbstract read
In one paragraph

Article in The Journal of physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Role of Caveolae and Caveolin in Vascular Physiology and Pathology.Journal of the American Heart Association · 2026
    Review
  6. Review
  7. Review
  8. Elastin Regulation of Vasoreactivity in Resistance Arteries.Hypertension (Dallas, Tex. : 1979) · 2025
    Article
  9. Article
  10. Nitrosation of CD36 Regulates Endothelial Function and Serum Lipids.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Single-Cell RNA-Seq Reveals Coronary Heterogeneity and Identifies CD133Arteriosclerosis, thrombosis, and vascular biology · 2024
    Article
  18. Article
  19. Cracking the Endothelial Calcium (CaInternational journal of molecular sciences · 2023
    Review
  20. Impact of aging on vascular ion channels: perspectives and knowledge gaps across major organ systems.American journal of physiology. Heart and circulatory physiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Matteo OttoliniRobert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, Charlottesville, VA, USA.
Zdravka DanevaRobert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, Charlottesville, VA, USA.
Yen-Lin ChenRobert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, Charlottesville, VA, USA.
Eric L CopeRobert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, Charlottesville, VA, USA.
Ramesh B KasettiDepartment of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX, USA.
Gulab S ZodeDepartment of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX, USA.
Swapnil K SonkusareRobert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, Charlottesville, VA, USA.ORCID 0000-0001-9587-9342
University of Virginia · USUniversity of North Texas · US

Funding

Paracrine TNF signaling impairs endothelial TRPV4 microdomains in obesityR01HL142808 · NHLBI · UNIVERSITY OF VIRGINIA · PI Swapnil K. Sonkusare · 2019 to 2026
$4.4M
Flow-Activated Calcium Signaling Microdomains in Small Pulmonary ArteriesR01HL146914 · NHLBI · UNIVERSITY OF VIRGINIA · PI Swapnil K. Sonkusare · 2019 to 2026
$3.8M
Crosstalk Between Unfolded Protein Response and Autophagy for the Treatment of GlaucomaR01EY026177 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ZODE, GULAB · 2016 to 2025
$3.8M
Targeting ER Stress Pathway Using Sodium 4-Phenylbutyrate for the Treatment of POAGR01EY028616 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ZODE, GULAB · 2018 to 2021
$1.4M
A novel TRPV4-eNOS signaling pathway in pulmonary endotheliumR56HL138496 · NHLBI · UNIVERSITY OF VIRGINIA · PI SONKUSARE, SWAPNIL K. · 2017 to 2017
$403k
NEI NIH HHS R01 EY026177NEI NIH HHS R01 EY028616NHLBI NIH HHS R01 HL142808NHLBI NIH HHS R01 HL146914NHLBI NIH HHS R56 HL138496NIH HHS HL138496NIH HHS HL142808NIH HHS HL146914
6 · The paper itself

Abstract

key pointsEndothelial cell TRPV4 (TRPV4 ABSTRACT: Spatially localized Ca

Indexed as

Nitric Oxide Synthase Type IIIPulmonary ArteryEndothelium, VascularMesenteric ArteriesVasodilationNitric Oxide Synthase Type IIICa2+ signallingendotheliumeNOSK+ channelsmesenteric arterypulmonary artery

Identifiers

PMID32463112
PMCPMC7484264
OpenAlexW3028669330

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.