ArticleMedical science monitor : international medical journal of experimental and clinical research2020
A Novel Vaccine Employing Non-Replicating Rabies Virus Expressing Chimeric SARS-CoV-2 Spike Protein Domains: Functional Inhibition of Viral/Nicotinic Acetylcholine Receptor Complexes.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Residual cardiopulmonary manifestations following COVID-19: a Tanzanian ambispective study.BMJ public health · 2025Article
- Clinical manifestations and treatment outcomes among hospitalised COVID-19 patients in tertiary hospitals in Tanzania, 2021-2022: a retrospective cohort study.BMJ public health · 2024Article
- The relation between vaccination status and referral to a consultation-liaison psychiatry service for hospitalized patients with COVID-19.BioPsychoSocial medicine · 2023Article
- Independent and sensory human mitochondrial functions reflecting symbiotic evolution.Frontiers in cellular and infection microbiology · 2023Review
- Article
- Altered cardiac autonomic function after recovery from COVID-19.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2022Article
- Mitochondrial DNA Heteroplasmy as an Informational Reservoir Dynamically Linked to Metabolic and Immunological Processes Associated with COVID-19 Neurological Disorders.Cellular and molecular neurobiology · 2022Review
- Nicotinic receptors as SARS-CoV-2 spike co-receptors?Medical hypotheses · 2022Article
- Biomedical Perspectives of Acute and Chronic Neurological and Neuropsychiatric Sequelae of COVID-19.Current neuropharmacology · 2022Article
- Immunogenicity and efficacy of mRNA COVID-19 vaccine MRT5500 in preclinical animal models.NPJ vaccines · 2021Article
- Neurological Complications of COVID-19: Underlying Mechanisms and Management.International journal of molecular sciences · 2021Review
- Convalescent Memory T Cell Immunity in Individuals with Mild or Asymptomatic SARS-CoV-2 Infection May Result from an Evolutionarily Adapted Immune Response to Coronavirus and the 'Common Cold'.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Long-Term Respiratory and Neurological Sequelae of COVID-19.Medical science monitor : international medical journal of experimental and clinical research · 2020Review
- Coronavirus pandemic: treatment and future prevention.Future microbiology · 2020Article
- The Current Status of COVID-19 Vaccines.Frontiers in genome editing · 2020Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence of the novel ß-coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a global pandemic of coronavirus disease 2019 (COVID-19). Clinical studies have documented that potentially severe neurological symptoms are associated with SARS-CoV-2 infection, thereby suggesting direct CNS penetration by the virus. Prior studies have demonstrated that the destructive neurological effects of rabies virus (RABV) infections are mediated by CNS transport of the virus tightly bound to the nicotinic acetylcholine receptor (nAChR). By comparison, it has been hypothesized that a similar mechanism exists to explain the multiple neurological effects of SARS-CoV-2 via binding to peripheral nAChRs followed by orthograde or retrograde transport into the CNS. Genetic engineering of the RABV has been employed to generate novel vaccines consisting of non-replicating RABV particles expressing chimeric capsid proteins containing human immunodeficiency virus 1 (HIV-1), Middle East respiratory syndrome (MERS-CoV), Ebolavirus, and hepatitis C virus (HCV) sequences. Accordingly, we present a critical discussion that integrates lessons learned from prior RABV research and vaccine development into a working model of a SARS-CoV-2 vaccine that selectively targets and neutralizes CNS penetration of a tightly bound viral nAChR complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.