ArticleBrain and behavior2020
Alterations of local functional connectivity in lifespan: A resting-state fMRI study.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large-scale resting-state functional brain networks in aging.Psychophysiology · 2023Pooled it
- Lights for aging: Can photobiomodulation restore functionality in the cerebral networks of aged individuals?Neural regeneration research · 2026Article
- Multiscale brain development across the human lifespan.Communications biology · 2026Review
- The effects of sex and age on movie-watching functional connectivity and movie clip classification.Brain structure & function · 2025Article
- Resting-state functional connectivity correlates of brain structural aging in schizophrenia.European archives of psychiatry and clinical neuroscience · 2025Article
- Influence of individual's age on the characteristics of brain effective connectivity.GeroScience · 2025Article
- Protective role of parenthood on age-related brain function in mid- to late-life.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Frailty links the heterogeneity of tinnitus disorder and response to interventions in older patients.Frontiers in neurology · 2025Review
- Article
- Functional network centrality indicates interactions between APOE4 and age across the clinical spectrum of Alzheimer's Disease.NeuroImage. Clinical · 2024Article
- Age-related differences in structural and resting-state functional brain network organization across the adult lifespan: A cross-sectional study.Aging brain · 2024Article
- PhiPipe: A multi-modal MRI data processing pipeline with test-retest reliability and predicative validity assessments.Human brain mapping · 2023Article
- Individual functional parcellation revealed compensation of dynamic limbic network organization in healthy ageing.Human brain mapping · 2023Article
- Characterizing the spatiotemporal features of functional connectivity across the white matter and gray matter during the naturalistic condition.Frontiers in neuroscience · 2023Article
- Person-Based Similarity Index for Cognition and Its Neural Correlates in Late Adulthood: Implications for Cognitive Reserve.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Thalamo-cortical inter-subject functional correlation during movie watching across the adult lifespan.Frontiers in neuroscience · 2022Article
- Co-sparse Non-negative Matrix Factorization.Frontiers in neuroscience · 2021Article
- A novel dynamic network imaging analysis method reveals aging-related fragmentation of cortical networks in mouse.Network neuroscience (Cambridge, Mass.) · 2021Article
- Alterations of local functional connectivity in lifespan: A resting-state fMRI study.Brain and behavior · 2020Article
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8 authors.
Funding
Abstract
introductionAs aging attracted attention globally, revealing changes in brain function across the lifespan was largely concerned. In this study, we aimed to reveal the changes of functional networks of the brain (via local functional connectivity, local FC) in lifespan and explore the mechanism underlying them. MATERIALS AND
methodsA total of 523 healthy participants (258 males and 265 females) aged 18-88 years from part of the Cambridge Center for Ageing and Neuroscience (CamCAN) were involved in this study. Next, two data-driven measures of local FC, local functional connectivity density (lFCD) and four-dimensional spatial-temporal consistency of local neural activity (FOCA), were calculated, and then, general linear models were used to assess the changes of them in lifespan.
resultsLocal functional connectivity (lFCD and FOCA) within visual networks (VN), sensorimotor network (SMN), and default mode network (DMN) decreased across the lifespan, while within basal ganglia network (BGN), local connectivity was increased across the lifespan. And, the fluid intelligence decreased within BGN while increased within VN, SMN, and DMN.
conclusionThese results might suggest that the decline of executive control and intrinsic cognitive ability in the aging population was related to the decline of functional connectivity in VN, SMN, and DMN. Meanwhile, BGN might play a regulatory role in the aging process to compensate for the dysfunction of other functional systems. Our findings may provide important neuroimaging evidence for exploring the brain functional mechanism in lifespan.
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