ReviewJPEN. Journal of parenteral and enteral nutrition2020
Nutrition Therapy in Critically Ill Patients With Coronavirus Disease 2019.
Review in JPEN. Journal of parenteral and enteral nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 6 syntheses or guidelines pooled it, 221 citations in OpenAlex.
- Naso-intestinal versus gastric tube for enteral nutrition in patients undergoing mechanical ventilation: a systematic review and meta-analysis.Systematic reviews · 2025Pooled it
- Effect of abdominal massage on feeding intolerance in patients receiving enteral nutrition: A systematic review and meta-analysis.Nursing open · 2023Pooled it
- Risk of Malnutrition in Hospitalized COVID-19 Patients: A Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- Effect of Omega-3 fatty acids supplementation on serum level of C-reactive protein in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials.Journal of translational medicine · 2022Pooled it
- The Effects of Enteral Nutrition in Critically Ill Patients with COVID-19: A Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- The Role of Nutrition in COVID-19 Susceptibility and Severity of Disease: A Systematic Review.The Journal of nutrition · 2021Pooled it
- Relationship between nutrition support and clinical outcomes in post-lung transplant patients in intensive care unit settings: A retrospective study.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026Article
- Article
- Early enteral nutrition may reduce the incidence of refeeding syndrome for patients with severe corona virus disease 2019 and high nutritional risk.Experimental and therapeutic medicine · 2026Article
- Implementation of the nutrition care process on mortality risk in critically ill COVID-19 patients - a registry longitudinal cohort study.Annals of medicine · 2025Article
- Nine Myths about Enteral Feeding in Critically Ill Adults: An Expert Perspective.Advances in nutrition (Bethesda, Md.) · 2025Review
- Impact of Nutritional Therapy during Intensive Care Unit Admission on Post-Intensive Care Syndrome in Patients with COVID-19.Annals of nutrition & metabolism · 2025Article
- Exploring Global Research Trends in Enteral Nutrition for Mechanically Ventilated Patients: A Comprehensive Bibliometric Study.Journal of multidisciplinary healthcare · 2025Review
- The dynamic linkage between covid-19 and nutrition: a review from a probiotics perspective using machine learning and bibliometric analysis.Frontiers in nutrition · 2025Article
- The Impact of Early Protein Advancement in Critically Ill Patients with COVID-19: A Multicenter Cardinality Matching Study.Therapeutics and clinical risk management · 2025Article
- Effectiveness and tolerance of enteral nutrition in critically ill patients with COVID-19.The British journal of nutrition · 2024Article
- The Influence of Prone Positioning on Energy and Protein Delivery in COVID-19 Patients Requiring ECMO Support.Nutrients · 2024Article
- Evaluation of malnutrition by objective nutritional indexes and predictors in hospitalized patients with COVID-19.Journal of clinical biochemistry and nutrition · 2024Article
- The association between enteral nutrition with survival of critical patients with COVID-19.Immunity, inflammation and disease · 2024Article
- Increased inpatient gastrostomy and jejunostomy tube placement during the 2020 COVID-19 pandemic.iGIE : innovation, investigation and insights · 2023Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the midst of a coronavirus disease 2019 (COVID-19) pandemic, a paucity of data precludes derivation of COVID-19-specific recommendations for nutrition therapy. Until more data are available, focus must be centered on principles of critical care nutrition modified for the constraints of this disease process, ie, COVID-19-relevant recommendations. Delivery of nutrition therapy must include strategies to reduce exposure and spread of disease by providing clustered care, adequate protection of healthcare providers, and preservation of personal protective equipment. Enteral nutrition (EN) should be initiated early after admission to the intensive care unit (ICU) using a standard isosmolar polymeric formula, starting at trophic doses and advancing as tolerated, while monitoring for gastrointestinal intolerance, hemodynamic instability, and metabolic derangements. Intragastric EN may be provided safely, even with use of prone-positioning and extracorporeal membrane oxygenation. Clinicians should have a lower threshold for switching to parenteral nutrition in cases of intolerance, high risk of aspiration, or escalating vasopressor support. Although data extrapolated from experience in acute respiratory distress syndrome warrants use of fiber additives and probiotic organisms, the lack of benefit precludes a recommendation for micronutrient supplementation. Practices that increase exposure or contamination of equipment, such as monitoring gastric residual volumes, indirect calorimetry to calculate requirements, endoscopy or fluoroscopy to achieve enteral access, or transport out of the ICU for additional imaging, should be avoided. At all times, strategies for nutrition therapy need to be assessed on a risk/benefit basis, paying attention to risk for both the patient and the healthcare provider.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.