Evidence map›Paper›PMID 32462417›Full record

ArticleJournal of assisted reproduction and genetics2020

The decision-making process, experience, and perceptions of preimplantation genetic testing (PGT) users.

Shachar Zuckerman, Sigal Gooldin, David A Zeevi, Gheona Altarescu

Open access · greenAbstract read
In one paragraph

Article in Journal of assisted reproduction and genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Expanded clinical validation of Haploseek for comprehensive preimplantation genetic testing.Genetics in medicine : official journal of the American College of Medical Genetics · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Shachar ZuckermanShaare Zedek Medical Center- Medical Genetics Institute, Jerusalem, Israel. Shachar.zuckerman@mail.huji.ac.il.
Sigal GooldinDepartment of Sociology and Anthropology, Hebrew University, Jerusalem, Israel.
David A ZeeviShaare Zedek Medical Center- Preimplantation Genetic Unit, Jerusalem, Israel.
Gheona AltarescuShaare Zedek Medical Center- Medical Genetics Institute, Jerusalem, Israel.
Shaare Zedek Medical Center · ILHebrew University of Jerusalem · IL

Funding

Hebrew University and the 'Israel National Institute for Health Policy Research' M\26\2010
6 · The paper itself

Abstract

purposeThe decision to undergo preimplantation genetic testing (PGT) entails a variety of personal and societal variables. Although PGT technology is widely accepted and used, few studies have queried the motives and concerns of PGT users; moreover, in-depth qualitative data regarding the PGT experience is scant.

methodsIn order to explore and analyze the experience, concerns, expectations, and attitudes toward the PGT technique and its implications, semi-structured interviews were conducted in a single tertiary medical center with 43 Israeli PGT users for HLA matching and autosomal dominant, autosomal recessive, and X-linked genetic disorders.

resultsThe primary considerations in choosing PGT were prevention of birth of a child who would suffer a terminal or chronic disease as well as abrogation of a familial genetic condition. Religion played a decisive role in accepting PGT as an antenatal option. Regarding satisfaction with the PGT experience, many interviewees highlighted the need for greater attention to be given to potential stages of failure throughout the procedure and the need for emotional support. Our clinical results regarding implantation rate and cumulative live birth rate are 38-40% and 27-30%, respectively.

conclusionThis survey broadens understanding of the specialized needs of women, couples, and minority groups undergoing PGT and underscores the relevance of counseling services for PGT users.

Indexed as

Fertilization in VitroPreimplantation DiagnosisAdultAneuploidyBirth RateClinical Decision-MakingEmbryo ImplantationEmbryo TransferFemaleGenetic TestingHumansMutationPregnancyExperiencesPGT usersPreimplantation genetic testingQualitative researchReproductive decision-making

Identifiers

PMID32462417
PMCPMC7468006
OpenAlexW3030620164

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.