ArticleEuropean journal of nuclear medicine and molecular imaging2020
Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer's disease.
Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Brain microstructure mediates the relationship between Alzheimer's proteinopathies and memory.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The Associations of cerebral blood flow and white matter hyperintensities with tau and amyloid-beta across the Alzheimer's disease spectrum.Brain imaging and behavior · 2026Article
- The Associations of Cerebral Blood Flow and White Matter Hyperintensities with Tau and Amyloid-beta Across the Alzheimer's Disease Spectrum.medRxiv : the preprint server for health sciences · 2026Article
- Visual Classification of Tau-PET Detects 4 Subtypes With Different Long-Term Outcomes.Neurology · 2025Article
- Plasma phosphorylated tau217 strongly associates with memory deficits in the Alzheimer's disease spectrum.Brain : a journal of neurology · 2025Article
- Anticipating the Future in an Uncertain Present: How Individuals Living With Medically Unexplained Cognitive Complaints Value Biomarker-Based Prognostics.Health expectations : an international journal of public participation in health care and health policy · 2025Article
- Uncovering cerebral blood flow patterns corresponding to Amyloid-beta accumulations in patients across the Alzheimer's disease continuum using the arterial spin labeling.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- TREM2 risk variants and associated endophenotypes in alzheimer's disease.Alzheimer's research & therapy · 2025Article
- The heart-brain axis: unraveling the interconnections between cardiovascular and Alzheimer's diseases.Frontiers in cardiovascular medicine · 2025Review
- Quantitative transport mapping of multi-delay arterial spin labeling MRI detects early blood perfusion alterations in Alzheimer's disease.Alzheimer's research & therapy · 2024Article
- Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition.Nature aging · 2024Article
- Quantitative transport mapping of multi-delay arterial spin labeling MRI detects early blood perfusion alteration in Alzheimer's disease.medRxiv : the preprint server for health sciences · 2024Article
- Test-retest performance of [Imaging neuroscience (Cambridge, Mass.) · 2024Article
- A review of the flortaucipir literature for positron emission tomography imaging of tau neurofibrillary tangles.Brain communications · 2024Review
- PET image denoising based on denoising diffusion probabilistic model.European journal of nuclear medicine and molecular imaging · 2024Article
- Associations of Multimorbidity with Cerebrospinal Fluid Biomarkers for Neurodegenerative Disorders in Early Parkinson's Disease: A Crosssectional and Longitudinal Study.Current Alzheimer research · 2024Article
- Mining Alzheimer's disease clinical data: reducing effects of natural aging for predicting progression and identifying subtypes.Frontiers in neuroscience · 2024Article
- Amyloid and tau pathology are associated with cerebral blood flow in a mixed sample of nondemented older adults with and without vascular risk factors for Alzheimer's disease.Neurobiology of aging · 2023Article
- Tau pathology as determinant of changes in atrophy and cerebral blood flow: a multi-modal longitudinal imaging study.European journal of nuclear medicine and molecular imaging · 2023Article
- Measurement of Cerebral Perfusion Indices from the Early Phase of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe aimed to investigate associations between tau pathology and relative cerebral blood flow (rCBF), and their relationship with cognition in Alzheimer's disease (AD), by using a single dynamic [
methodsSeventy-one subjects with AD (66 ± 8 years, mini-mental state examination (MMSE) 23 ± 4) underwent a dynamic 130-min [
conclusionTau pathology was associated with locally reduced rCBF. Tau pathology and low rCBF were both independently associated with worse cognitive performance. For tau pathology, these associations spanned widespread neocortex, while for rCBF, independent associations were restricted to lateral temporal and parietal regions and the executive functioning and attention domains. These findings indicate that each biomarker may independently contribute to cognitive impairment in AD.
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