ReviewJournal of neurology2021
An update on idiopathic intracranial hypertension in adults: a look at pathophysiology, diagnostic approach and management.
Review in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06059703 (Biomarkers in the Etiology of Idiopathic Intracranial Hypertension), which is not on this map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- The Effect of Metabolic and Bariatric Surgery on Patients with Idiopathic Intracranial Hypertension; A Systematic Review and Meta-analysis.Obesity surgery · 2025Pooled it
- Evaluation of CSF pressures, OCT parameters, and transorbital ultrasonographic measurements in ıdiopathic ıntracranial hypertension.International ophthalmology · 2026Article
- Idiopathic Intracranial Hypertension with and Without Papilledema: A Comparative Cohort Study.Brain sciences · 2026Article
- Clinical Symptoms of Jugular Venous Outflow Obstruction and Their Modification After Targeted Surgical Treatment.Neurosurgery practice · 2026Article
- Pseudotumor Cerebri Syndrome and Essential Thrombocythemia: A Case Report.Clinical case reports · 2026Article
- Inflammation in Idiopathic Intracranial Hypertension: An Immunometabolic Mechanistic Framework and Clinical Implications.CNS neuroscience & therapeutics · 2026Review
- Neurofilament light chain levels as a biomarker in idiopathic intracranial hypertension: correlations with papilledema and radiological findings.Acta neurologica Belgica · 2026Article
- MRI findings in pediatric idiopathic intracranial hypertension: evaluating the oculomotor nerve sheath as a potential new diagnostic marker.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Papilledema With Facial and Vestibulocochlear Nerve Involvement in Idiopathic Intracranial Hypertension: An Unusual Case.Case reports in ophthalmological medicine · 2026Article
- Factors Influencing Favourable Clinical Outcomes in Idiopathic Intracranial Hypertension with Venous Sinus Stenosis Stenting.Clinical neuroradiology · 2025Article
- Stenting versus balloon angioplasty alone for idiopathic intracranial hypertension.Quantitative imaging in medicine and surgery · 2024Article
- A Review of the Clinical Presentation, Causes, and Diagnostic Evaluation of Increased Intracranial Pressure in the Emergency Department.The western journal of emergency medicine · 2024Review
- Tortuous occipital emissary vein combined with dural venous sinus stenosis in contrast-enhanced MRV for evaluation of idiopathic intracranial hypertension.Japanese journal of radiology · 2024Article
- An interdisciplinary integrated specialized one-stop outpatient clinic for idiopathic intracranial hypertension-a comprehensive assessment of clinical outcome.European journal of neurology · 2024Article
- Activation of Piezo1 by intracranial hypertension induced neuronal apoptosis via activating hippo pathway.CNS neuroscience & therapeutics · 2024Article
- Unilateral Papilledema with Bilateral Optic Nerve Sheath Distension: A Case Report.Turkish journal of ophthalmology · 2024Article
- An interdisciplinary integrated specialized one-stop outpatient clinic for idiopathic intracranial hypertension - a comprehensive assessment of patient satisfaction.The journal of headache and pain · 2024Article
- Regulation of brain fluid volumes and pressures: basic principles, intracranial hypertension, ventriculomegaly and hydrocephalus.Fluids and barriers of the CNS · 2024Review
- An interdisciplinary integrated specialized one-stop outpatient clinic for idiopathic intracranial hypertension - an assessment of sick leave, presenteeism, and health care utilization.The journal of headache and pain · 2024Article
- Longitudinal optical coherence tomography indices in idiopathic intracranial hypertension.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Idiopathic intracranial hypertension is a neurological syndrome determined by a rise in intracranial pressure without a detectable cause. Course and prognosis may be changeable, requiring a multidisciplinary approach for its diagnosis and management. Although its precise pathogenesis is still unknown, many studies have been carried out to define the possible causal and associated factors, such as retinoids, steroid hormones, body mass index and recent weight gains, cytokines and adipokines levels. The clinical presentation can be variable including chronic headache, disturbance of vision, diplopia and tinnitus. Even if papilloedema is considered the most specific sign, it could not be observed in more than 5% of patients during the evaluation of the fundus oculi. Neuroradiological signs acquire greater importance in patients who do not present papilloedema and may suggest the diagnosis of idiopathic intracranial hypertension. Other assessments can be useful in the diagnostic process, such as optical coherence tomography, visual evoked potentials, ocular ultrasonography and fundus fluorescein angiography and autofluorescence. Nonetheless, cerebrospinal fluid pressure measurement is required to establish a definite diagnosis. Management may be different, since surgical procedures or lumbar punctures are often required when symptoms develop rapidly leading to a loss of visual function. Apart from these cases, patients can be treated with a pharmacological approach and low-calorie diet, but they also need to be monitored over time since relapses years later are not uncommon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.