Evidence map›Paper›PMID 32462316›Full record

ReviewJournal of endocrinological investigation2020

SARS-CoV-2 infection, male fertility and sperm cryopreservation: a position statement of the Italian Society of Andrology and Sexual Medicine (SIAMS) (Società Italiana di Andrologia e Medicina della Sessualità).

G Corona, E Baldi, A M Isidori, D Paoli, F Pallotti, L De Santis, F Francavilla, S La Vignera, R Selice, L Caponecchia and 7 more

Registry-linked trialOpen access · bronzeAbstract readReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of endocrinological investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05379556 (LOng COvid COmorbidities), which is not on this map. Cited by 61 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 5 pooled it
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05379556 recruitingnot on this mapstarted 2022, after this paper: background citation

LOng COvid COmorbidities: Evaluation of Andrological, Reproductive and Sexual Functions in Patients Recovered From COVID-19

TypeobservationalSponsorFederico II UniversityRan2022 to 2027Enrolled100ConditionsLong Covid-19ArmsAssessment of andrological profile of LO-COCO-ANDRO male patients, Assessment of reproductive function of LO-COCO-ANDRO male patients, Assessment of sexual function of LO-COCO-ANDRO male patients, Assessment of olfactory function of LO-COCO-ANDRO male and female patients
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 5 syntheses or guidelines pooled it, 99 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Review
  8. Oncofertility: Treatment options from bench to bedside.Cancer pathogenesis and therapy · 2023
    Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Investigating Impacts of CoronaVac Vaccination in Males onThe world journal of men's health · 2022
    Article
  16. Article
  17. Growing concerns on male reproductive health amidst COVID-19 pandemic.Journal of family medicine and primary care · 2022
    Review
  18. Article
  19. Could SARS-CoV-2 infection affect male fertility and sexuality?APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2022
    Review
  20. Post-COVID Pain Syndromes.Current pain and headache reports · 2022
    Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 11 institutions in 1 country.

G CoronaEndocrinology Unit, Medical Department, Maggiore-Bellaria Hospital, Largo Nigrisoli 2, 40133, Bologna, Italy. jocorona@libero.it.ORCID http://orcid.org/0000-0002-9894-2885
E BaldiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.ORCID http://orcid.org/0000-0003-1808-3097
A M IsidoriDepartment of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0002-9037-5417
D PaoliDepartment of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0002-9699-8703
F PallottiDepartment of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0001-6042-6474
L De SantisIVF Unit, Gynaecological-Obstetric Department, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy.ORCID http://orcid.org/0000-0001-8540-9988
F FrancavillaAndrology Unit, Department of Clinical Medicine, Public Health, Life and Environment Sciences, University of L'Aquila, L'Aquila, Italy.ORCID http://orcid.org/0000-0003-1255-4062
S La VigneraDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.ORCID http://orcid.org/0000-0002-7113-2372
R SeliceDepartment of Medicine, Unit of Andrology and Reproductive Medicine, University of Padova, Padova, Italy.ORCID http://orcid.org/0000-0001-5699-8461
L CaponecchiaAndrology and Pathophysiology of Reproduction Unit, Santa Maria Goretti Hospital, Latina, Italy.ORCID http://orcid.org/0000-0002-0779-6449
R PivonelloDipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Unità di Andrologia e Medicina della Riproduzione e della Sessualità Maschile e Femminile (FERTISEXCARES), Università Federico II di Napoli; Staff of Unesco Chair for Health Education and Sustainable Development, Federico II University, Naples, Italy.ORCID http://orcid.org/0000-0002-9632-1348
A FerlinDepartment of Clinical and Experimental Sciences, Unit of Endocrinology and Metabolism, University of Brescia, Brescia, Italy.ORCID http://orcid.org/0000-0001-5817-8141
C ForestaDepartment of Medicine, Unit of Andrology and Reproductive Medicine, University of Padova, Padova, Italy.ORCID http://orcid.org/0000-0002-6576-2183
E A JanniniChair of Endocrinology and Medical Sexology (ENDOSEX), Department of Systems Medicine, University of Rome Tor Vergata, Roma, Italy.ORCID http://orcid.org/0000-0002-5874-039X
A LenziDepartment of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0002-7711-0465
M MaggiEndocrinology Unit, Department of Experimental Clinical and Biomedical Sciences ``Mario Serio'', University of Florence, Florence, Italy.ORCID http://orcid.org/0000-0003-3267-4221
F LombardoDepartment of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0002-6943-2966
Sapienza University of Rome · ITUniversity of Florence · ITUniversity of Padua · ITFederico II University Hospital · ITOspedale Maggiore · ITOspedale Santa Maria Goretti · ITUniversity of Brescia · ITUniversity of Catania · ITUniversity of L'Aquila · ITUniversity of Rome Tor Vergata · ITVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe recent pandemic of severe acute respiratory syndrome (SARS) due to coronavirus (CoV) 2 (SARS-CoV-2) has raised several concerns in reproductive medicine. The aim of this review is to summarize available evidence providing an official position statement of the Italian Society of Andrology and Sexual Medicine (SIAMS)

methodsA comprehensive Pubmed, Web of Science, Embase, Medline and Cochrane library search was performed. Due to the limited evidence and the lack of studies, it was not possible to formulate recommendations according to the Oxford 2011 Levels of Evidence criteria.

resultsSeveral molecular characteristics of the SARS-CoV-2 can justify the presence of virus within the testis and possible alterations of spermatogenesis and endocrine function. Orchitis has been reported as a possible complication of SARS-CoV infection, but similar findings have not been reported for SARS-CoV-2. Alternatively, the orchitis could be the result of a vasculitis as COVID-19 has been associated with abnormalities in coagulation and the segmental vascularization of the testis could account for an orchitis-like syndrome. Finally, available data do not support the presence of SARS-CoV-2 in plasma seminal fluid of infected subjects.

conclusionData derived from other SARS-CoV infections suggest that in patients recovered from COVID-19, especially for those in reproductive age, andrological consultation and evaluation of gonadal function including semen analysis should be suggested. Studies in larger cohorts of currently infected subjects are warranted to confirm (or exclude) the presence of risks for male gametes that are destined either for cryopreservation in liquid nitrogen or for assisted reproduction techniques.

Indexed as

BetacoronavirusAndrologyCoronavirus InfectionsCOVID-19CryopreservationFertility PreservationHumansItalyMalePandemicsPneumonia, ViralSARS-CoV-2Semen AnalysisSexual HealthSocieties, MedicalSpermatozoaCOVID-19Male fertilitySARS-CoV-2Semen cryopreservation

Identifiers

PMID32462316
PMCPMC7252417
OpenAlexW3031905811

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.