Evidence map›Paper›PMID 32462296›Full record

ArticleJournal of cancer research and clinical oncology2020

Des-gamma-carboxy prothrombin affects the survival of HCC patients with marginal liver function and curative treatment: ACRoS1402.

Atsushi Kudo, Masahiro Shinoda, Shunichi Ariizumi, Takafumi Kumamoto, Masafumi Katayama, Takehito Otsubo, Itaru Endo, Yuko Kitagawa, Minoru Tanabe, Masakazu Yamamoto and 1 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Atsushi KudoDepartment of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan. kudomsrg@tmd.ac.jp.ORCID http://orcid.org/0000-0002-5301-3847
Masahiro ShinodaDepartment of Surgery, School of Medicine, Keio University, Tokyo, Japan.
Shunichi AriizumiDepartment of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Takafumi KumamotoDepartment of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University, Kanagawa, Japan.
Masafumi KatayamaDivision of Gastroenterological and General Surgery, St. Marianna University School of Medicine, Kanagawa, Japan.
Takehito OtsuboDivision of Gastroenterological and General Surgery, St. Marianna University School of Medicine, Kanagawa, Japan.
Itaru EndoDepartment of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University, Kanagawa, Japan.
Yuko KitagawaDepartment of Surgery, School of Medicine, Keio University, Tokyo, Japan.
Minoru TanabeDepartment of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Masakazu YamamotoDepartment of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Association for Clinical Research on Surgery Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeConsidering the initial treatment of hepatocellular carcinoma (HCC), the best prognostic index for Child-Pugh classes B and C (CP-BC) patients has not been yet established. This study aimed to elucidate the risk factors for disease-free survival (DFS) and overall survival (OS) in multicenter patients with a poor liver functional reserve after curative treatment.

methodsBetween April 2000 and April 2014, 212 CP-BC patients who received treatment in five high-volume centers in Japan were included in this study. CP-B and C patients were 206 and 6, respectively. Cox proportional hazard regression analyses for DFS and OS were performed to estimate the risk factors.

resultsThe mean observation time was 1132 days. Mean Child-Pugh score and indocyanine green retention rate at 15 min were 7.5 and 31.5%, respectively. Histological chronic hepatitis and liver cirrhosis were observed in 20% and 74% patients, respectively. In the multivariate analysis, the risk factors for DFS were des-gamma-carboxy prothrombin (DCP) [hazard ratio (HR), 1.6; P = 0.012] and treatment without liver transplantation. Moreover, DCP was identified as an independent risk factor for OS (HR, 1.7; P = 0.01). Tumor size, number, tumor thrombus, Milan criteria, liver cirrhosis, and treatment without liver transplantation were not identified as risk factors for OS. The 5-year OS in patients with high serum DCP levels (< 90 mAU/mL) was significantly better than that in those with low serum DCP levels (P = 0.003).

conclusionsSerum DCP value before treatment predicted both DFS and OS in CP-BC patients with HCC.

Indexed as

AgedBiomarkersBiomarkers, TumorCarcinoma, HepatocellularDisease-Free SurvivalFemaleHumansLiver NeoplasmsMaleMiddle AgedProtein PrecursorsProthrombinacarboxyprothrombinBiomarkersBiomarkers, TumorProtein PrecursorsProthrombinAblation therapyChild–pugh class B and CHepatectomyHepatocellular carcinomaLiver transplatationPoor liver functional reserveSafety

Identifiers

PMID32462296
PMCPMC11804317

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.