Evidence map›Paper›PMID 32462086›Full record

ArticleHeliyon2020

Cocaine has some effect on neuromedin U expressing neurons related to the brain reward system.

Madoka Anan, Ryoko Higa, Kenshiro Shikano, Masahito Shide, Akinobu Soda, Magdeline E Carrasco Apolinario, Kenji Mori, Toshitaka Shin, Mikiya Miyazato, Hiromitsu Mimata and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Neuromedin U, a Key Molecule in Metabolic Disorders.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Madoka AnanDepartment of Neurophysiology, Faculty of Medicine, Oita University, Oita, Japan.
Ryoko HigaDepartment of Neurophysiology, Faculty of Medicine, Oita University, Oita, Japan.
Kenshiro ShikanoDepartment of Neurophysiology, Faculty of Medicine, Oita University, Oita, Japan.
Masahito ShideDepartment of Neurophysiology, Faculty of Medicine, Oita University, Oita, Japan.
Akinobu SodaDepartment of Neurophysiology, Faculty of Medicine, Oita University, Oita, Japan.
Magdeline E Carrasco ApolinarioDepartment of Neurophysiology, Faculty of Medicine, Oita University, Oita, Japan.
Kenji MoriDepartment of Biochemistry, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
Toshitaka ShinDepartment of Urology, Faculty of Medicine, Oita University, Oita, Japan.
Mikiya MiyazatoDepartment of Biochemistry, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
Hiromitsu MimataDepartment of Urology, Faculty of Medicine, Oita University, Oita, Japan.
Takatoshi HikidaLaboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University, Osaka, Japan.
Toshikatsu HanadaDepartment of Cell Biology, Faculty of Medicine, Oita University, Oita, Japan.
Kazuwa NakaoMedical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kenji KangawaDepartment of Biochemistry, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
Reiko HanadaDepartment of Neurophysiology, Faculty of Medicine, Oita University, Oita, Japan.
Oita University · JPNational Cerebral and Cardiovascular Center · JPKyoto University · JPProtein Research Foundation · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuromedin U (NMU) is a bioactive neuropeptide, highly distributed in the gastrointestinal tract and the central nervous system. NMU has various physiological functions related to feeding behavior, energy metabolism, stress responses, circadian rhythmicity and inflammation. Recently, several reports indicate that the central NMU system plays an important role in the reward systems in the brain. However, the underlying molecular mechanisms are not yet fully defined. In this study, we found that some of cocaine-induced c-Fos immunoreactive cells were co-localized with NMU in the nucleus accumbens (NAc), caudate putamen (CPu), and basolateral amygdala (BLA), which are key brain regions associated with the brain reward system, in wild type mice. Whereas, a treatment with cocaine did not influence the kinetics of NMU or NMU receptors mRNA expression in these brain regions, and NMU-knockout mice did not show any higher preference for cocaine compared with their control mice. These results indicate that cocaine has some effect on NMU expressing neurons related to the brain reward system, and this suggests NMU system may have a role on the brain reward systems activated by cocaine.

Indexed as

Addiction medicineBehavioral medicineBiological psychiatryBLABrain reward systemc-FosCocaineCPP testCPuEndocrinologyMouseNAcNeuromedin UNeuropeptideNeurosciencePhysiology

Identifiers

PMID32462086
PMCPMC7240118
OpenAlexW3027408473

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.