ArticleJournal of clinical tuberculosis and other mycobacterial diseases2020
Challenges in the diagnosis of tuberculous meningitis.
Article in Journal of clinical tuberculosis and other mycobacterial diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers, 2 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Cerebral tuberculoma in pregnancy (Jan 1975-May 2025): a systematic review and descriptive analysis of 33 published cases.BMC infectious diseases · 2026Pooled it
- Meta-analysis of diagnostic accuracy of nucleic acid amplification tests for abdominal tuberculosis.PloS one · 2023Pooled it
- Evaluation of Microbiological and Neuroimaging Diagnostic Modalities in Tuberculous Meningitis in Children: A Prospective Observational Study from Rural India.Annals of African medicine · 2026Observational
- Basal Ganglia Ischemic Stroke as Sentinel Sign for Pediatric Tuberculous Meningitis in an Immunocompetent Child: A Case Report.Pediatric reports · 2026Article
- Diagnosis of Tuberculous Meningitis: Integrating Clinical Assessment and Molecular Diagnostics.Diagnostics (Basel, Switzerland) · 2026Review
- Article
- The progress of tuberculous meningitis medical management in adults.Surgical neurology international · 2026Review
- [Beyond the puncture site: discordance between ventricular and lumbar CSF in paediatric tuberculous meningitis].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2025Article
- Intraspinal and intracranial Neurotuberculosis: A case report.Journal of clinical tuberculosis and other mycobacterial diseases · 2025Article
- Tuberculous Meningitis Complicated by Communicating Hydrocephalus and Lacunar Infarcts: A Case Report.Cureus · 2025Article
- A case of tuberculous meningitis triggered by long-term use of corticosteroids drugs.Annals of medicine and surgery (2012) · 2025Article
- Validation of UV-Vis spectrophotometric colorimetric methods for Rifampicin quantification in PBS & biological matrices.Bioanalysis · 2025Article
- Central nervous system tuberculosis in Western Sydney: a 10-year retrospective cohort study.Internal medicine journal · 2025Article
- Mortality predictors and diagnostic challenges in adult tuberculous meningitis: a retrospective cohort of 100 patients.Tropical medicine and health · 2025Article
- Tuberculosis: An Update for the Clinician.Respirology (Carlton, Vic.) · 2025Review
- Intracranial manifestations of central nervous system tuberculosis in children.Pediatric radiology · 2025Review
- Ophthalmoplegia and vision loss in extrapulmonary tuberculosis with bilateral cavernous sinus involvement.IDCases · 2025Article
- The diagnostic potential of urine in paediatric patients undergoing initial treatment for tuberculous meningitis.Scientific reports · 2024Article
- A case report of tuberculous meningitis resulting in irreversible visual impairment due to delayed diagnosis.Clinical case reports · 2024Article
- Analysis of risk factors for long-term mortality in patients with stage II and III tuberculous meningitis.BMC infectious diseases · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tuberculosis (TB) continues to pose a significant public health problem. Tuberculous meningitis (TBM) is the most severe form of extra-pulmonary TB. TBM carries a high mortality rate, including for those receiving treatment for TB. Diagnosis of TBM is difficult for clinicians as it can clinically present similarly to other forms of meningitis. The difficulty in diagnosis often leads to a delay in treatment and subsequent mortality. Those who survive are left with long-term sequelae leading to lifelong disability. The microbiologic diagnosis of TBM requires the isolation of Mycobacterium tuberculosis from the cerebrospinal fluid (CSF) of an infected patient. The diagnosis of tuberculous meningitis continues to be challenging for clinicians. Unfortunately, many cases of TBM cannot be confirmed based on clinical and imaging findings as the clinical findings are nonspecific, while laboratory techniques are largely insensitive or slow. Until recently, the lack of accessible and timely tests has contributed to a delay in diagnosis and subsequent morbidity and mortality for many patients, particularly those in resourcelimited settings. The availability of Xpert Ultra and point-of-care lipoarabinomannan (LAM) testing could represent a new era of prompt diagnosis and early treatment of tuberculous meningitis. However, clinicians must be cautious when ruling out TBM with Xpert Ultra due to its low negative predictive value. Due to the limitations of current diagnostics, clinicians should utilize a combination of diagnostic modalities in order to prevent morbidity in patients with TBM.
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