ReviewOpen forum infectious diseases2020
Fever and Fever of Unknown Origin: Review, Recent Advances, and Lingering Dogma.
Review in Open forum infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 138 citations in OpenAlex.
- Body surface temperatures as biomarkers of physiological environmental adaptation in wild birds and mammals.Biological reviews of the Cambridge Philosophical Society · 2026Pooled it
- Functional Hyperthermia Presenting as Fever of Unknown Origin With Normal Inflammatory Markers in an Adolescent.Journal of general and family medicine · 2026Article
- Risk factors associated with apyrexia during bacteraemia: a prospective multicenter cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- FUO-PETMamba: a pet maximum-intensity-projection-based artificial intelligence framework for aetiological classification of fever of unknown origin with multicentre validation.European journal of nuclear medicine and molecular imaging · 2026Article
- Beyond Prosthetic Valve Infection: Anchoring Bias Delaying the Diagnosis of Synovial Sarcoma.Cureus · 2026Article
- State-of-the-Art Review: Contemporary Ambulatory Approach to Adult Fever of Unknown Origin.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Review
- Long-Term Follow-Up of Patients With Classic Fever of Unknown Origin: Prognostic Outcomes and Management Strategies.Open forum infectious diseases · 2026Article
- Article
- Distinguishing lymphoma from benign lymphadenopathy in fever of unknown origin using a diagnostic model based on PET/CT and clinical-laboratory parameters.EJNMMI research · 2026Article
- Granulomatosis With Polyangiitis: A Case of a 62-Year-Old Female Presenting With a Fever of Unknown Origin.Cureus · 2026Article
- Navigating the Diagnosis of Atypical Still's Disease in the Absence of the Characteristic Rash.Cureus · 2026Article
- Pyrexia of Unknown Origin (PUO) in South Asia: A Systematic Review of Diagnostic Gaps and Management Strategies.Research square · 2026Article
- Institutional Readiness and Diagnostic Challenges for the Management of Pyrexia of Unknown Origin (PUO) in Nepal: A Mixed-Methods Study at Tertiary Level Hospitals.Research square · 2026Article
- Observational
- Clinical application value of metagenomic next-generation sequencing in children with fever of unknown origin.Frontiers in pediatrics · 2026Article
- Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Unsupervised clustering of PET/CT features in fever of unknown origin (FUO) and inflammation of unknown origin (IUO).Frontiers in medicine · 2026Article
- Sarcolipin-SERCA uncoupling as a plausible heat source for sustaining fever.Frontiers in physiology · 2026Article
- Acute Adult-Onset Still Disease Presenting as Fever of Unknown Origin and Severe Myalgia in a Resource-Limited Tertiary Hospital in Brazil.Case reports in medicine · 2026Article
- Fever of unknown origin (FUO): a 7-year clinical experience, etiological distribution, and diagnostic approaches.BMC infectious diseases · 2025Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fever has preoccupied physicians since the earliest days of clinical medicine. It has been the subject of scrutiny in recent decades. Historical convention has mostly determined that 37.0°C (98.6°F) should be regarded as normal body temperature, and more modern evidence suggests that fever is a complex physiological response involving the innate immune system and should not be characterized merely as a temperature above this threshold. Fever of unknown origin (FUO) was first defined in 1961 by Petersdorf and Beeson and continues to be a clinical challenge for physicians. Although clinicians may have some understanding of the history of clinical thermometry, how average body temperatures were established, thermoregulation, and pathophysiology of fever, new concepts are emerging. While FUO subgroups and etiologic classifications have remained unchanged since 1991 revisions, the spectrum of diseases, clinical approach to diagnosis, and management are changing. This review considers how newer data should influence both definitions and lingering dogmatic principles. Despite recent advances and newer imaging techniques such as 18-fluorodeoxyglucose-positron emission tomography, clinical judgment remains an essential component of care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.