Evidence map›Paper›PMID 32462037›Full record

ArticleBioMed research international2020

Effects of Cardiac Sympathetic Neurodegeneration and PPAR

Jeanette M Metzger, Mary S Lopez, Jenna K Schmidt, Megan E Murphy, Raghu Vemuganti, Marina E Emborg

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jeanette M MetzgerPreclinical Parkinson's Research Program, Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, 53706 WI, USA.
Mary S LopezCellular and Molecular Pathology Graduate Program, University of Wisconsin-Madison, Madison, 53706 WI, USA.
Jenna K SchmidtPreclinical Parkinson's Research Program, Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, 53706 WI, USA.
Megan E MurphyPreclinical Parkinson's Research Program, Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, 53706 WI, USA.
Raghu VemugantiCellular and Molecular Pathology Graduate Program, University of Wisconsin-Madison, Madison, 53706 WI, USA.
Marina E EmborgPreclinical Parkinson's Research Program, Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, 53706 WI, USA.ORCID https://orcid.org/0000-0002-9351-6641
University of Wisconsin–Madison · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
ncRNAs and PPARy-Induced Sympathetic Neuroprotection in an NHP Model of Cardiac NeurodegenerationF31HL136047 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI METZGER, JEANETTE · 2017 to 2018
$63k
NHLBI NIH HHS F31 HL136047NIH HHS P51 OD011106
6 · The paper itself

Abstract

Degeneration of sympathetic innervation of the heart occurs in numerous diseases, including diabetes, idiopathic REM sleep disorder, and Parkinson's disease (PD). In PD, cardiac sympathetic denervation occurs in 80-90% of patients and can begin before the onset of motor symptoms. Today, there are no disease-modifying therapies for cardiac sympathetic neurodegeneration, and biomarkers are limited to radioimaging techniques. Analysis of expression levels of coding mRNA and noncoding RNAs, such as microRNAs (miRNAs), can uncover pathways involved in disease, leading to the discovery of biomarkers, pathological mechanisms, and potential drug targets. Whole blood in particular is a clinically relevant source of biomarkers, as blood sampling is inexpensive and simple to perform. Our research group has previously developed a nonhuman primate model of cardiac sympathetic denervation by intravenous administration of the catecholaminergic neurotoxin 6-hydroxydopamine (6-OHDA). In this rhesus macaque (

Indexed as

AnimalsBiomarkersCytokinesHeartInflammationMacaca mulattaMaleMicroRNAsNeurodegenerative DiseasesOxidative StressOxidopamineParkinson DiseasePPAR gammaRNA, MessengerTranscriptomeBiomarkersCytokinesMicroRNAsOxidopaminePPAR gammaRNA, Messenger

Identifiers

PMID32462037
PMCPMC7212295
OpenAlexW3022719683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.