SynthesisBioMed research international2020
Low-Frequency Repetitive Transcranial Magnetic Stimulation for the Treatment of Chronic Tinnitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Synthesis in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Neuromodulation for Subjective Tinnitus: A Systematic Review and Meta-Analysis of Randomized Trials.The Laryngoscope · 2026Pooled it
- Efficacy of repetitive transcranial magnetic stimulation for subjective chronic tinnitus: a randomized controlled trial meta-analysis.Frontiers in neuroscience · 2025Pooled it
- Guideline
- Multiple Daily Rounds of Theta-Burst Stimulation for Tinnitus: Preliminary Results.Medicina (Kaunas, Lithuania) · 2021Trial
- Tinnitus and tinnitus disorder: Genetic, neurobiological, and clinical differentiation.iScience · 2026Review
- Analysis of clinical characteristics and predictive model for effective treatment of tinnitus in patients with transient compound sound therapy.Frontiers in neurology · 2024Article
- Tinnitus Guidelines and Their Evidence Base.Journal of clinical medicine · 2023Article
- Activate & fire: a feasibility study in combining acoustic stimulation and continuous theta burst stimulation in chronic tinnitus.BMC neurology · 2023Article
- EEG spectral and microstate analysis originating residual inhibition of tinnitus induced by tailor-made notched music training.Frontiers in neuroscience · 2023Article
- Effect of electrical stimulation with a cochlear implant on tinnitus impact: protocol of an individual patient data meta-analysis.BMJ open · 2022Article
- Chronic Tinnitus.Deutsches Arzteblatt international · 2022Review
- Current Status of Neuromodulation-Induced Cortical Prehabilitation and Considerations for Treatment Pathways in Lower-Grade Glioma Surgery.Life (Basel, Switzerland) · 2022Review
- Sequential Prefrontal and Temporoparietal Repetitive Transcranial Magnetic Stimulation (rTMS) for Treatment of Tinnitus With and Without Comorbid Depression: A Case Series and Systematic Review.Frontiers in neurology · 2022Article
- Implications of Transcranial Magnetic Stimulation as a Treatment Modality for Tinnitus.Journal of clinical medicine · 2021Review
- Heading for Personalized rTMS in Tinnitus: Reliability of Individualized Stimulation Protocols in Behavioral and Electrophysiological Responses.Journal of personalized medicine · 2021Article
- Animal Models of Tinnitus Treatment: Cochlear and Brain Stimulation.Current topics in behavioral neurosciences · 2021Article
- Repetitive Transcranial Magnetic Stimulation for Tinnitus Treatment in Vestibular Schwannoma: A Pilot Study.Frontiers in neurology · 2021Article
- Tinnitus and Brain Stimulation.Current topics in behavioral neurosciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic tinnitus affects approximately 10-15% of the population. Low-frequency repetitive transcranial magnetic stimulation (rTMS) has been considered as a promising and well-tolerated therapeutic strategy for chronic tinnitus. However, a recent large-scale multicenter clinical trial showed a negative result.
objectiveThis systematic review is aimed at assessing the efficacy and safety of low-frequency rTMS in chronic tinnitus.
methodsWe searched PubMed, Embase, and Cochrane Library for randomized controlled studies of rTMS treatment of chronic tinnitus. A pooled analysis of standardized mean difference (SMD) was performed with 95% confidence intervals (CI).
resultsTen RCTs involving 567 participants were included in this review. Compared with sham stimulation, rTMS showed no significant efficacy in tinnitus severity and disability measured by Tinnitus Handicap Inventory (THI) in short-term (SMD = -0.04, 95% CI -0.23 to 0.16,
conclusionLow-frequency rTMS is well tolerated but not effective in treating chronic tinnitus based on the current analysis of pooled data. Further studies with modified and uniform protocols are required to investigate the potential benefit of rTMS in chronic tinnitus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.