ArticleNature2020
Origin of complexity in haemoglobin evolution.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 82 papers.
0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
82 citing papers in PubMed, 187 citations in OpenAlex.
- Mechanisms of Phenotypic Evolution from Molecules to Organisms: Integrating Evolutionary Biochemistry and Evolutionary Developmental Biology.Annual review of ecology, evolution, and systematics · 2026Article
- Ancestral proteins trace the emergence of substrate specificity and oligomerization within bacterial DEDDy dinucleases.Science advances · 2026Article
- Redox implications of oxygen binding in hemoglobin and myoglobin: Thermodynamics of the (FeJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026Article
- Emergence of specific binding and catalysis from a designed generalist binding protein.Nature chemistry · 2026Article
- Evolutionary causes and consequences of gene duplication.Nature reviews. Genetics · 2026Review
- Origins of allostery in vertebrate hemoglobin evolution.bioRxiv : the preprint server for biology · 2026Article
- Machine learning for evolutionary genetics and molecular evolution.Trends in genetics : TIG · 2026Review
- Mass spectrometry reveals the evolutionary conservation of phycobiliprotein complexes.Nature communications · 2026Article
- Cascading chirality from molecule to twisted microstructures with amplified circularly polarized luminescence.Nature communications · 2026Article
- Directed evolution of multimeric proteins is enabled by dual-compensatory gene duplication.bioRxiv : the preprint server for biology · 2026Article
- Divergence of immune cell types in chordate blood.Current biology : CB · 2025Article
- Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters.Nature structural & molecular biology · 2025Article
- Electrostatic changes enabled the diversification of an exocyst subunit via protein complex escape.Nature plants · 2025Article
- In situ structure of a bacterial flagellar motor at subnanometre resolution reveals adaptations for increased torque.Nature microbiology · 2025Article
- Theoretical evaluation of the biological activity of hydrogen.Medical gas research · 2025Review
- Frustration in physiology and molecular medicine.Molecular aspects of medicine · 2025Review
- Immune cell type divergence in a basal chordate.bioRxiv : the preprint server for biology · 2025Article
- Simple genetic mechanisms toward more intricate molecular complexes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Transcriptomic Data Reveal Divergent Paths of Chitinase Evolution Underlying Dietary Convergence in Anteaters and Pangolins.Genome biology and evolution · 2025Article
- Symmetry facilitated the evolution of heterospecificity and high-order stoichiometry in vertebrate hemoglobin.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
10 authors at 4 institutions in 3 countries.
Arvind S PillaiDepartment of Ecology and Evolution, University of Chicago, Chicago, IL, USA.
Shane A Chandler *Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, UK.
Yang Liu *Department of Chemistry, Texas A&M University, College Station, TX, USA.ORCID http://orcid.org/0000-0003-4994-5200
Anthony V Signore *School of Biological Sciences, University of Nebraska, Lincoln, NE, USA.ORCID http://orcid.org/0000-0002-0664-0864
Carlos R Cortez-RomeroProgram in Cell and Molecular Biology, University of Chicago, Chicago, IL, USA.
Justin L P BeneschDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-1507-3742
Arthur LaganowskyDepartment of Chemistry, Texas A&M University, College Station, TX, USA.
Jay F StorzSchool of Biological Sciences, University of Nebraska, Lincoln, NE, USA.
Georg K A HochbergDepartment of Ecology and Evolution, University of Chicago, Chicago, IL, USA.
Joseph W ThorntonDepartment of Ecology and Evolution, University of Chicago, Chicago, IL, USA. joet1@uchicago.edu.ORCID http://orcid.org/0000-0001-9589-6994
University of Chicago · USTexas A&M University · USUniversity of Nebraska–Lincoln · USUniversity of Oxford · GB
Funding
PREDOCTORAL TRAINING IN GENETICS AND REGULATIONT32GM007197 · NIGMS · UNIVERSITY OF CHICAGO · PI ROTHMAN-DENES, LUCIA B. B · 1985 to 2020
$17.0MUniversity of Chicago Initiative for Maximizing Student Development (IMSD) - Renewal 01R25GM109439 · NIGMS · UNIVERSITY OF CHICAGO · PI SCHWARTZ, NANCY B · 2014 to 2023
$5.7MMutational Pleiotropy, Epistasis, and the Adaptive Evolution of Hemoglobin FunctionR01HL087216 · NHLBI · UNIVERSITY OF NEBRASKA LINCOLN · PI STORZ, JAY · 2008 to 2021
$4.5MDeep characterization of the sequence space and evolutionary trajectories of reconstructed ancestral proteins - Resubmission 01R01GM121931 · NIGMS · UNIVERSITY OF CHICAGO · PI THORNTON, JOSEPH W · 2017 to 2020
$1.3MEvolution of molecular complexes: genetic, structural, and functional mechanisms for the evolution of oligomers and allosteryR01GM131128 · NIGMS · UNIVERSITY OF CHICAGO · PI THORNTON, JOSEPH W · 2019 to 2021
$904kNHLBI NIH HHS R01 HL087216NIGMS NIH HHS R01 GM121931NIGMS NIH HHS R01 GM131128NIGMS NIH HHS R25 GM109439NIGMS NIH HHS T32 GM007197
Abstract
Most proteins associate into multimeric complexes with specific architectures
Indexed as
Evolution, MolecularAllosteric RegulationBinding SitesHemeHemoglobinsHumansIronModels, MolecularOxygenProtein MultimerizationProtein Structure, QuaternaryProtein SubunitsHemeHemoglobinsIronOxygenProtein Subunits
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.