ArticleNature2020
The stepwise assembly of the neonatal virome is modulated by breastfeeding.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 180 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
180citing papers in PubMed, 2 pooled it
29.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
180 citing papers in PubMed, 2 syntheses or guidelines pooled it, 291 citations in OpenAlex.
- A meta-analysis of infant gut viromes reveals global patterns in bacteriophage community assembly and functional capacity over the first three years of life.Nature communications · 2026Pooled it
- Phage diversity in human breast milk: a systematic review.European journal of pediatrics · 2025Pooled it
- Trial
- Effect of Avoiding Cow's Milk Formula at Birth on Prevention of Asthma or Recurrent Wheeze Among Young Children: Extended Follow-up From the ABC Randomized Clinical Trial.JAMA network open · 2020Trial
- Gut microbiome and pregnancy complications: emerging evidence and mechanistic insights.Gut microbes · 2026Review
- The enteric DNA virome differs in infants at risk for atopic disease.Gut microbes · 2026Article
- Maternal and infant gut microbiome.iMeta · 2026Review
- Optimizing methods for virome analysis based on studies of a synthetic viral community.mSystems · 2026Article
- Protecting Newborns from Multidrug-Resistant Infections: The Emerging Role of Bacteriophages.Viruses · 2026Review
- The human skin virome: Ecological dynamics, aberrant profiles, and therapeutic opportunities.Cell host & microbe · 2026Review
- The Unified Human Virome Database: A toolkit for expanded human virome analysis.bioRxiv : the preprint server for biology · 2026Article
- Multi-kingdom profiling reveals altered gut phage-bacteria-metabolite interactions in MASLD.Nature communications · 2026Article
- Unveiling the viral dimension: The paediatric gut virome as a key modulator of gastrointestinal metabolic, and neurodevelopmental health.World journal of virology · 2026Review
- DNA Viral Size Fraction Metagenomics for Human Stool Samples.Journal of visualized experiments : JoVE · 2026Article
- Impact of phage enrichment on the observed infant gut phageome.Microbiology spectrum · 2026Article
- Article
- Article
- First-year dynamics of the plasma virome and cytokine profile in infants born to mothers with syphilis.Journal of translational medicine · 2026Article
- Gut virome dynamics: from commensal to critical player in health and disease.Nature reviews. Gastroenterology & hepatology · 2026Review
- Temporal dynamics of gut microbiota and virome in preterm infants: insights from longitudinal metagenomic analysis.Frontiers in cellular and infection microbiology · 2026Article
120 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 4 institutions in 2 countries.
Guanxiang LiangDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Chunyu ZhaoDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Huanjia ZhangDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Lisa MatteiDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-2238-0281
Scott Sherrill-MixDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kyle BittingerDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Lyanna R KesslerDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-0021-7969
Gary D WuDivision of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Robert N BaldassanoDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Patricia DeRussoDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Eileen FordDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Michal A ElovitzMaternal and Child Health Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Matthew S KellyDivision of Pediatric Infectious Diseases, Duke University, Durham, NC, USA.
Mohamed Z PatelDepartment of Paediatric and Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana.
Tiny MazhaniDepartment of Paediatric and Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana.
Jeffrey S GerberDivision of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Andrea KellyDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Babette S ZemelDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-6164-7348
Frederic D BushmanDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. bushman@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0003-4740-4056
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · USUniversity of Botswana · BWDuke University · US
Funding
Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4MVirus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ROBERT GROSS · 1999 to 2026
$78.6MSocial and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5MInstitutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9MInfant Growth and Microbiome Study 2R01DK107565 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI WU, GARY D., ZEMEL, BABETTE S · 2015 to 2019
$3.6MLung Transplant Microbiome and Chronic Allograft DysfunctionR01HL113252 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BUSHMAN, FREDERIC D, CHRISTIE, JASON D · 2013 to 2016
$2.9MNasopharyngeal Microbiome and Risk of Bacterial Pathogen Colonization in InfantsK23AI135090 · NIAID · DUKE UNIVERSITY · PI KELLY, MATTHEW SCOTT · 2018 to 2022
$860kThe Lung DNA Virome in Health and DiseaseR61HL137063 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BUSHMAN, FREDERIC D, COLLMAN, RONALD G · 2017 to 2018
$605kNCATS NIH HHS UL1 TR000003NCATS NIH HHS UL1 TR001878NHLBI NIH HHS R01 HL113252NHLBI NIH HHS R61 HL137063NIAID NIH HHS K23 AI135090NIAID NIH HHS P30 AI045008NIAID NIH HHS P30 AI064518NIDDK NIH HHS R01 DK107565
Abstract
The gut of healthy human neonates is usually devoid of viruses at birth, but quickly becomes colonized, which-in some cases-leads to gastrointestinal disorders
Indexed as
Breast FeedingAdultBacteriolysisBacteriophagesFecesFemaleGastrointestinal MicrobiomeGastrointestinal TractHumansInfantInfant, NewbornLysogenyMaleMeconiumProphagesViruses
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.