ArticleNature communications2020
Genome and single-cell RNA-sequencing of the earthworm Eisenia andrei identifies cellular mechanisms underlying regeneration.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- The therapeutic potential of transposable element activity modulation.EMBO molecular medicine · 2026Review
- DNA Methylation Dynamics inBiomolecules · 2026Article
- Single-cell analyses of tissue regeneration in two true jellyfish.Molecular biology and evolution · 2026Article
- Host-transposon mutualism supports regeneration in planarians.Developmental cell · 2026Article
- Insights into the architecture of earthworm metallothionein genes, powered by long-read genomics and transcriptomics.NAR genomics and bioinformatics · 2026Article
- LumbriCyc: towards metabolic modelling of earthworms.NPJ systems biology and applications · 2026Article
- Integrated transcriptomic and metabolomic ecotoxicity assessment of earthworms exposed to ZnO and Mn-doped ZnO nanomaterials.Frontiers in toxicology · 2026Article
- Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum).Advanced biology · 2025Article
- Article
- A genome resource for the marine annelid Platynereis spp.BMC genomics · 2025Article
- An episodic burst of massive genomic rearrangements and the origin of non-marine annelids.Nature ecology & evolution · 2025Article
- The high-quality telomere-to-telomere genome assembly of the earthworm (Amynthas aspergillum).Scientific data · 2025Article
- Advances and applications in single-cell and spatial genomics.Science China. Life sciences · 2025Review
- Chromosome-level genome assembly and single-cell analysis unveil molecular mechanisms of arm regeneration in the ophiuroid Ophiura sarsii vadicola.Genome biology · 2025Article
- Advancing ex vivo functional whole-organ prostate gland model for regeneration and drug screening.Scientific reports · 2025Article
- Degenerated vision, altered lipid metabolism, and expanded chemoreceptor repertoires enable Lindaspio polybranchiata to thrive in deep-sea cold seeps.BMC biology · 2025Article
- Omics in mini-livestock: a genomic perspective on the future of sustainable food systems.Frontiers in genetics · 2025Review
- Molecular profiles, sources and lineage restrictions of stem cells in an annelid regeneration model.Nature communications · 2024Article
- De-novo transcriptome of anterior epimorphic regeneration in Perionyx excavatus.Scientific data · 2024Article
- SoxC and MmpReg promote blastema formation in whole-body regeneration of fragmenting potworms Enchytraeus japonensis.Nature communications · 2024Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The earthworm is particularly fascinating to biologists because of its strong regenerative capacity. However, many aspects of its regeneration in nature remain elusive. Here we report chromosome-level genome, large-scale transcriptome and single-cell RNA-sequencing data during earthworm (Eisenia andrei) regeneration. We observe expansion of LINE2 transposable elements and gene families functionally related to regeneration (for example, EGFR, epidermal growth factor receptor) particularly for genes exhibiting differential expression during earthworm regeneration. Temporal gene expression trajectories identify transcriptional regulatory factors that are potentially crucial for initiating cell proliferation and differentiation during regeneration. Furthermore, early growth response genes related to regeneration are transcriptionally activated in both the earthworm and planarian. Meanwhile, single-cell RNA-sequencing provides insight into the regenerative process at a cellular level and finds that the largest proportion of cells present during regeneration are stem cells.
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