ArticleNature communications2020
Hippocampal seed connectome-based modeling predicts the feeling of stress.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Drawbacks to Strengthening Neural Salience Encoding: A Link Between Cortisol and Risky Drinking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Trial
- Sex matters for the enhancement of cognitive training with transcranial direct current stimulation (tDCS).Biology of sex differences · 2023Trial
- Candidate Targets for Resilience Training to Reduce Transdiagnostic Risk for Mental Illness.Schizophrenia bulletin · 2026Article
- Objective sleep efficiency links to cortisol stress recovery via dorsolateral prefrontal-hippocampal regulation.Psychological medicine · 2026Article
- Distinct neurologic state in patients with traumatic brain injury and hemorrhagic stroke during the stage of acute disorders of consciousness and the correlation with the neurological prognosis: A multi-modal PET/rs-fMRI study.NeuroImage. Clinical · 2026Article
- Sex difference in neural substrates linking negative body image and disordered eating behaviors.Brain structure & function · 2025Article
- Loneliness in schizophrenia: Just loneliness.Annals of the New York Academy of Sciences · 2025Review
- Dysregulated responses to stress and alcohol cues in cortico-striatal-limbic regions in social drinkers with early trauma.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Burnout and the Brain-A Mechanistic Review of Magnetic Resonance Imaging (MRI) Studies.International journal of molecular sciences · 2025Review
- Trauma-predictive brain network connectivity adaptively responds to mild acute stress.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Pre-pandemic mental health and brain characteristics predict adolescent stress and emotions during the COVID-19 pandemic.PloS one · 2025Article
- Dynamic changes in the hippocampal neuronal circuits activity following acute stress revealed by miniature fluorescence microscopy imaging.Molecular brain · 2024Article
- Neural foundation of the diathesis-stress model: longitudinal gray matter volume changes in response to stressful life events in major depressive disorder and healthy controls.Molecular psychiatry · 2024Article
- Altered brain and physiological stress responses in early psychosis.Schizophrenia research · 2024Article
- Metacognition as a window into subjective affective experience.Psychiatry and clinical neurosciences · 2024Review
- Acute Stress Effects on Statistical Learning and Episodic Memory.Journal of cognitive neuroscience · 2024Article
- Dissecting the networks underlying diverse brain disorders after prenatal glucocorticoid overexposure.Archives of toxicology · 2024Review
- Connectome-based machine learning models are vulnerable to subtle data manipulations.Patterns (New York, N.Y.) · 2023Article
- Psychological stress: neuroimmune roles in periodontal disease.Odontology · 2023Review
- Binge drinking is associated with higher cortisol and lower hippocampal and prefrontal gray matter volume: Prospective association with future alcohol intake.Neurobiology of stress · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Although the feeling of stress is ubiquitous, the neural mechanisms underlying this affective experience remain unclear. Here, we investigate functional hippocampal connectivity throughout the brain during an acute stressor and use machine learning to demonstrate that these networks can specifically predict the subjective feeling of stress. During a stressor, hippocampal connectivity with a network including the hypothalamus (known to regulate physiological stress) predicts feeling more stressed, whereas connectivity with regions such as dorsolateral prefrontal cortex (associated with emotion regulation) predicts less stress. These networks do not predict a subjective state unrelated to stress, and a nonhippocampal network does not predict subjective stress. Hippocampal networks are consistent, specific to the construct of subjective stress, and broadly informative across measures of subjective stress. This approach provides opportunities for relating hypothesis-driven functional connectivity networks to clinically meaningful subjective states. Together, these results identify hippocampal networks that modulate the feeling of stress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.