ArticleThe Journal of veterinary medical science2020
Effect of high-concentrate corn grain diet-induced elevated ruminal lipopolysaccharide levels on dairy cow liver function.
Article in The Journal of veterinary medical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Exploring the Regulatory Mechanism of Sodium Butyrate on Milk Fat Synthesis in Lactating Goats Fed a High-Concentrate Diet Based on Metabolomics Technology.Physiological research · 2026Article
- Ruminal tannase-producing bacteria and their effects on growth performance, nutrient digestibility, blood parameters, and rumen bacterial populations in weaning Afshar-Kurdi lambs fed pomegranate peel.Tropical animal health and production · 2026Article
- Microplastics induce liver inflammation in cattle through the rumen microbiota-gut-liver axis.Microbiome · 2026Article
- Free Fatty Acids and Endotoxins Synergically Induce Pyroptosis in Bovine Hepatocytes.Metabolites · 2026Article
- Immune-Modulatory Mechanism of Compound Yeast Culture in the Liver of Weaned Lambs.Animals : an open access journal from MDPI · 2025Article
- Ileal microbial microbiome and its secondary bile acids modulate susceptibility to nonalcoholic steatohepatitis in dairy goats.Microbiome · 2024Article
- Effects of grain intervention on hypothalamic function and the metabolome of blood and milk in dairy cows.Journal of animal science and biotechnology · 2024Article
- Article
- High rumen degradable starch diet induced blood bile acids profile changes and hepatic inflammatory response in dairy goats.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Ameliorative effects of supranutritional selenium on TLR-4-NF-kB-TNF-α-mediated hepatic oxidative injury and inflammation in goats fed high concentrate diet.Food science & nutrition · 2022Article
- Growth Performance, Rumen Fermentation and Inflammatory Response on Holstein Growing Cattle Treated with Low and High Non-Fibrous Carbohydrate to Neutral Detergent Fiber Ratio Pelleted Total Mixed Ration.Animals : an open access journal from MDPI · 2022Article
- Changes in immune system and intestinal bacteria of cows during the transition period.Veterinary and animal science · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A high-concentrate diet destroys gram-negative bacteria in the cattle rumen, leading to elevated ruminal lipopolysaccharide (LPS) levels. LPS causes liver inflammation through the hepatic portal vein but little is known about the effects of rumen-derived LPS on liver function and the reproductive organs. In this study, we determined the effect of increasing rumen fluid LPS levels on liver function and genital LPS levels. Cows were assigned to control (CON; n=5) and high-concentrate diet (HC; n=7) groups. We observed that the ruminal LPS and haptoglobin (Hp) levels were significantly higher and albumin levels were lower in the HC group than in the CON group. In the HC group, The Hp levels and aspartate transaminase (AST) activity were significantly higher and the total cholesterol levels were significantly lower after high-concentrate diet feeding than before feeding. No differences were observed in LPS levels in the peripheral veins, hepatic veins, hepatic portal vein, uterine perfusate, and follicular fluids between the groups. In all samples, the LPS level in the hepatic portal vein blood positively correlated with the AST activity and serum amyloid A level. In conclusion, our results indicate that high-concentrate diets do not have a direct effect on the reproductive organs upon a moderate ruminal LPS level increase. However, an increased ruminal LPS influx into the liver might affect negatively liver function.
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