ArticleProceedings of the National Academy of Sciences of the United States of America2020
Context-dependent and dynamic functional influence of corticothalamic pathways to first- and higher-order visual thalamus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Metabotropic Glutamatergic Signaling Adaptively Controls Trans-thalamic Communication.bioRxiv : the preprint server for biology · 2026Article
- Layer 6 corticothalamic neurons show diverse and dynamic responses that support a role in cortical gain control in noisy environments.bioRxiv : the preprint server for biology · 2026Article
- Learning-dependent 4 Hz synchronization in the posterior striatum, lateral geniculate nucleus, and visual cortex.iScience · 2025Article
- Article
- Layer 6 Corticothalamic Neurons Induce High Gamma Oscillations Through Cortico-cortical and Cortico-thalamo-cortical Pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Complementary Organization of Mouse Driver and Modulator Cortico-thalamo-cortical Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- FOXP2-immunoreactive corticothalamic neurons in neocortical layers 6a and 6b are tightly regulated by neuromodulatory systems.iScience · 2025Article
- Experience-dependent plasticity of multiple receptive field properties in lateral geniculate binocular neurons during the critical period.Frontiers in cellular neuroscience · 2025Article
- Article
- Motor Control of Distinct Layer 6 Corticothalamic Feedback Circuits.bioRxiv : the preprint server for biology · 2024Article
- Dynamic corticothalamic modulation of the somatosensory thalamocortical circuit during wakefulness.Nature communications · 2024Article
- A mechanism for deviance detection and contextual routing in the thalamus: a review and theoretical proposal.Frontiers in neuroscience · 2024Article
- Article
- Purkinje cell microzones mediate distinct kinematics of a single movement.Nature communications · 2023Article
- Primary somatosensory cortex bidirectionally modulates sensory gain and nociceptive behavior in a layer-specific manner.Nature communications · 2023Article
- Rabies virus-based labeling of layer 6 corticothalamic neurons for two-photon imagingiScience · 2023Article
- Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep.Cell reports · 2023Article
- Selective corticofugal modulation on sound processing in auditory thalamus of awake marmosets.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Brain State-Dependent Modulation of Thalamic Visual Processing by Cortico-Thalamic Feedback.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Experience-dependent functional plasticity and visual response selectivity of surviving subplate neurons in the mouse visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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3 authors.
Funding
Abstract
Layer 6 (L6) is the sole purveyor of corticothalamic (CT) feedback to first-order thalamus and also sends projections to higher-order thalamus, yet how it engages the full corticothalamic circuit to contribute to sensory processing in an awake animal remains unknown. We sought to elucidate the functional impact of L6CT projections from the primary visual cortex to the dorsolateral geniculate nucleus (first-order) and pulvinar (higher-order) using optogenetics and extracellular electrophysiology in awake mice. While sustained L6CT photostimulation suppresses activity in both visual thalamic nuclei in vivo, moderate-frequency (10 Hz) stimulation powerfully facilitates thalamic spiking. We show that each stimulation paradigm differentially influences the balance between monosynaptic excitatory and disynaptic inhibitory corticothalamic pathways to the dorsolateral geniculate nucleus and pulvinar, as well as the prevalence of burst versus tonic firing. Altogether, our results support a model in which L6CTs modulate first- and higher-order thalamus through parallel excitatory and inhibitory pathways that are highly dynamic and context-dependent.
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