Evidence map›Paper›PMID 32461362›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Adenine DNA methylation, 3D genome organization, and gene expression in the parasite

Ayelen Lizarraga, Zach Klapholz O'Brown, Konstantinos Boulias, Lara Roach, Eric Lieberman Greer, Patricia J Johnson, Pablo H Strobl-Mazzulla, Natalia de Miguel

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Chromatin Interaction Maps of Trypanosoma cruzi.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Targeting histone acetylation to overcome drug resistance in the parasitebioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ayelen LizarragaLaboratorio de Parásitos Anaerobios, Instituto Tecnológico Chascomús, National Scientific and Technical Research Council-National University of San Martin (CONICET-UNSAM), B7130IWA Chascomús, Argentina.
Zach Klapholz O'BrownDivision of Newborn Medicine, Children's Hospital Boston, Boston, MA 02115.
Konstantinos BouliasDivision of Newborn Medicine, Children's Hospital Boston, Boston, MA 02115.
Lara RoachDivision of Newborn Medicine, Children's Hospital Boston, Boston, MA 02115.ORCID 0000-0003-2534-6588
Eric Lieberman GreerDivision of Newborn Medicine, Children's Hospital Boston, Boston, MA 02115.ORCID 0000-0002-7501-7371
Patricia J JohnsonDepartment of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095; johnsonp@ucla.edu ndemiguel@intech.gov.ar.
Pablo H Strobl-MazzullaLaboratorio de Biología del Desarrollo, Instituto Tecnológico Chascomús, CONICET-UNSAM, B7130IWA Chascomús, Argentina.ORCID 0000-0003-0591-6168
Natalia de MiguelLaboratorio de Parásitos Anaerobios, Instituto Tecnológico Chascomús, National Scientific and Technical Research Council-National University of San Martin (CONICET-UNSAM), B7130IWA Chascomús, Argentina; johnsonp@ucla.edu ndemiguel@intech.gov.ar.ORCID 0000-0002-3864-0703
Boston Children's Hospital · USConsejo Nacional de Investigaciones Científicas y Técnicas · ARUniversity of California, Los Angeles · US

Funding

Characterization of DNA N6-methyl adenine and its role in epigenetic memoryDP2AG055947 · NIA · BOSTON CHILDREN'S HOSPITAL · PI GREER, ERIC LIEBERMAN · 2016 to 2021
$3.2M
Gene Expression in Trichomonas vaginalisR01AI030537 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JOHNSON, PATRICIA JEAN · 1991 to 2008
$2.7M
Base-resolution sequencing of 6mA in eukaryotic DNAR21HG010066 · NHGRI · BOSTON CHILDREN'S HOSPITAL · PI GREER, ERIC LIEBERMAN · 2018 to 2019
$487k
NHGRI NIH HHS R21 HG010066NIAID NIH HHS R01 AI030537NIA NIH HHS DP2 AG055947
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdenineAscorbic AcidCell Culture TechniquesChromatinComputational BiologyDNA MethylationDNA Transposable ElementsGene Expression RegulationHigh-Throughput Nucleotide SequencingMolecular ConformationSequence Analysis, DNATrichomonas vaginalisAdenineAscorbic AcidChromatinDNA Transposable Elementsadenine methylationgene expressionTrichomonas

Identifiers

PMID32461362
PMCPMC7293704
OpenAlexW3029119626

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.