Evidence map›Paper›PMID 32461316›Full record

ArticleJournal of virology2020

Better Viral Control despite Higher CD4

Elina El-Badry, Gladys Macharia, Daniel Claiborne, Kelsie Brooks, Darío A Dilernia, Paul Goepfert, William Kilembe, Susan Allen, Jill Gilmour, Eric Hunter

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. The HIV Reservoir and Immune Landscape Across the Life Course of Women: Implications for Cure Strategies.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. A viral-specific CD4Frontiers in immunology · 2023
    Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Elina El-BadryEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Gladys MachariaDepartment of Medicine, Imperial College London, London, United Kingdom.
Daniel ClaiborneEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Kelsie BrooksEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Darío A DilerniaEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Paul GoepfertDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
William KilembeZambia-Emory HIV Research Project, Lusaka, Zambia.
Susan AllenZambia-Emory HIV Research Project, Lusaka, Zambia.
Jill GilmourDepartment of Medicine, Imperial College London, London, United Kingdom.
Eric HunterEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA ehunte4@emory.edu.ORCID 0000-0002-4273-8631
Emory University · USInternational HIV/AIDS Alliance · GBUniversity of Alabama at Birmingham · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0M
CTL and HIV Polymorphisms in Heterosexual TransmissionR01AI064060 · NIAID · EMORY UNIVERSITY · PI GOEPFERT, PAUL A., HUNTER, ERIC · 2005 to 2019
$21.7M
Virologic Correlates of Heterosexual TransmissionR01AI051231 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ALLEN, TODD M, HUNTER, ERIC · 2002 to 2022
$9.9M
VCT with Primary and Concurrent Partners to Prevent HIV Transmission R01MH095503 · NIMH · EMORY UNIVERSITY · PI ALLEN, SUSAN A · 2011 to 2016
$2.5M
NIAID NIH HHS P30 AI050409NIAID NIH HHS R01 AI051231NIAID NIH HHS R01 AI064060NIH HHS P51 OD011132NIMH NIH HHS R01 MH095503
6 · The paper itself

Abstract

The influence of biological sex on disease progression in HIV-1-infected individuals has been focused on the chronic stage of infection, but little is known about how sex differences influence acute HIV-1 infection. We observed profound differences in viral load and CD4

Indexed as

AdultCD4 Lymphocyte CountCD4-Positive T-LymphocytesCohort StudiesDisease ProgressionEstradiolFemaleGonadal Steroid HormonesHIV-1HIV InfectionsHumansLymphocyte ActivationMaleViral LoadVirus ReplicationZambiaEstradiolGonadal Steroid Hormonesestrogenhuman immunodeficiency virussex differencesT cell activationviral loadviral pathogenesisviral replication

Identifiers

PMID32461316
PMCPMC7394904
OpenAlexW3030811533

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.