Evidence map›Paper›PMID 32461236›Full record

ArticleDisease models & mechanisms2020

Extracellular matrix induced by steroids and aging through a G-protein-coupled receptor in a

Wenjing Zheng, Karen Ocorr, Marc Tatar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease models & mechanisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Cells · 2025
    Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Wenjing ZhengDepartment of Ecology and Evolutionary Biology, Division of Biology and Medicine, Brown University, Providence RI 02912, USA.
Karen OcorrDevelopment, Aging and Regeneration Program, SBP Medical Discovery Institute, La Jolla, CA 92037, USA.
Marc TatarDepartment of Ecology and Evolutionary Biology, Division of Biology and Medicine, Brown University, Providence RI 02912, USA Marc_Tatar@Brown.edu.ORCID 0000-0003-3232-6884
Brown University · USDiscovery Institute · US

Funding

Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4M
GENETIC ANALYSIS OF SLEEP SENECENCEP01AG033561 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI BODMER, ROLF · 2011 to 2015
$6.3M
FUNCTIONS AND INTERACTIONS DFOXO IN DROSOPHILA AGINGR37AG024360 · NIA · BROWN UNIVERSITY · PI TATAR, MARC · 2011 to 2020
$4.5M
Cellular/molecular substrates linking channel dysfunction and pathological cardiac remodelingR01HL132241 · NHLBI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI OCORR, KAREN · 2017 to 2020
$1.9M
Cellular Mediators of Cardiac Aging and Arrhythmia in DrosophilaR21AG061598 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI OCORR, KAREN · 2019 to 2020
$536k
NHLBI NIH HHS R01 HL132241NIA NIH HHS P01 AG033561NIA NIH HHS R21 AG061598NIA NIH HHS R37 AG024360NIDDK NIH HHS U24 DK076169
6 · The paper itself

Abstract

Aldosterone is produced by the mammalian adrenal cortex to modulate blood pressure and fluid balance; however, excessive, prolonged aldosterone promotes fibrosis and kidney failure. How aldosterone triggers disease may involve actions independent of its canonical mineralocorticoid receptor. Here, we present a

Indexed as

Age FactorsAldosteroneAnimalsAnimals, Genetically ModifiedCollagen Type IVDisease Models, AnimalDrosophila melanogasterDrosophila ProteinsEcdysoneErbB ReceptorsExtracellular MatrixFibrosisKidneyKidney DiseasesMyocytes, CardiacReceptors, Invertebrate PeptideAldosteroneCollagen Type IVDrosophila ProteinsEcdysoneecdysone receptorEgfr protein, DrosophilaErbB ReceptorsPrc protein, DrosophilaReceptors, Invertebrate PeptideReceptors, SteroidAgingAldosteroneDopEcREcdysoneFibrosisG-protein-coupled receptor

Identifiers

PMID32461236
PMCPMC7328168
OpenAlexW3028837381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.