Evidence map›Paper›PMID 32461224›Full record

ArticleGenome research2020

Paternal age in rhesus macaques is positively associated with germline mutation accumulation but not with measures of offspring sociability.

Richard J Wang, Gregg W C Thomas, Muthuswamy Raveendran, R Alan Harris, Harshavardhan Doddapaneni, Donna M Muzny, John P Capitanio, Predrag Radivojac, Jeffrey Rogers, Matthew W Hahn

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 75 citations in OpenAlex.

  1. EstimatingbioRxiv : the preprint server for biology · 2026
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  5. Census and genetic analysis of the United States marmoset population.bioRxiv : the preprint server for biology · 2026
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  9. Review
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  12. Population size interacts with reproductive longevity to shape the germline mutation rate.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
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  15. Article
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  20. Characterizing the rates and patterns ofbioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Richard J WangDepartment of Biology, Indiana University, Bloomington, Indiana 47405, USA.ORCID 0000-0002-8889-4269
Gregg W C ThomasDepartment of Biology, Indiana University, Bloomington, Indiana 47405, USA.
Muthuswamy RaveendranHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
R Alan HarrisHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Harshavardhan DoddapaneniHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Donna M MuznyHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
John P CapitanioCalifornia National Primate Research Center, University of California-Davis, Davis, California 95616, USA.
Predrag RadivojacDepartment of Computer Science, Indiana University, Bloomington, Indiana 47405, USA.
Jeffrey RogersHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Matthew W HahnDepartment of Biology, Indiana University, Bloomington, Indiana 47405, USA.ORCID 0000-0002-5731-8808
Baylor College of Medicine · USIndiana University Bloomington · USNortheastern University · USUniversity of California, Davis · US

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Social Regulation of Gene Expression, SupplementR37AG033590 · NIA · UNIVERSITY OF CHICAGO · PI CACIOPPO, JOHN T. · 2010 to 2017
$3.5M
Biobehavioral characterization of infant rhesus monkeysR24OD010962 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CAPITANIO, JOHN P · 2012 to 2018
$2.5M
NIA NIH HHS R37 AG033590NIH HHS P51 OD011107NIH HHS R24 OD010962
6 · The paper itself

Abstract

Mutation is the ultimate source of all genetic novelty and the cause of heritable genetic disorders. Mutational burden has been linked to complex disease, including neurodevelopmental disorders such as schizophrenia and autism. The rate of mutation is a fundamental genomic parameter and direct estimates of this parameter have been enabled by accurate comparisons of whole-genome sequences between parents and offspring. Studies in humans have revealed that the paternal age at conception explains most of the variation in mutation rate: Each additional year of paternal age in humans leads to approximately 1.5 additional inherited mutations. Here, we present an estimate of the de novo mutation rate in the rhesus macaque (

Indexed as

Behavior, AnimalGerm-Line MutationMutation AccumulationPaternal AgeSocial SkillsAge FactorsAnimalsFemaleHumansMacaca mulattaMaleMutation RatePregnancyPrenatal Exposure Delayed EffectsSpecies Specificity

Identifiers

PMID32461224
PMCPMC7370888
OpenAlexW3032093788

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.