Evidence map›Paper›PMID 32461223›Full record

ArticleGenome research2020

Quantitative analysis of Y-Chromosome gene expression across 36 human tissues.

Alexander K Godfrey, Sahin Naqvi, Lukáš Chmátal, Joel M Chick, Richard N Mitchell, Steven P Gygi, Helen Skaletsky, David C Page

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 125 citations in OpenAlex.

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  14. Age-Related Transcriptomic Changes in the Vermiform Appendix.International journal of molecular sciences · 2025
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Alexander K GodfreyWhitehead Institute, Cambridge, Massachusetts 02142, USA.ORCID 0000-0002-5681-3225
Sahin NaqviWhitehead Institute, Cambridge, Massachusetts 02142, USA.ORCID 0000-0003-2635-7967
Lukáš ChmátalWhitehead Institute, Cambridge, Massachusetts 02142, USA.ORCID 0000-0002-0861-9006
Joel M ChickDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Richard N MitchellDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.ORCID 0000-0002-0329-7618
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.ORCID 0000-0001-7626-0034
Helen SkaletskyWhitehead Institute, Cambridge, Massachusetts 02142, USA.ORCID 0000-0002-2724-3673
David C PageWhitehead Institute, Cambridge, Massachusetts 02142, USA.ORCID 0000-0001-9920-3411
Whitehead Institute for Biomedical Research · USHarvard University · USHoward Hughes Medical Institute · USBrigham and Women's Hospital · US

Funding

PRE-DOCTORAL TRAINING IN THE BIOLOGICAL SCIENCEST32GM007287 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELL, STEPHEN P., KEATING, AMY E · 1985 to 2019
$40.8M
VASCULAR, PULMONARY AND RENAL INJURYT32HL007627 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GIMBRONE, MICHAEL A, MITCHELL, RICHARD N · 1985 to 2019
$12.7M
New Sample Multiplexing Technologies to Identify Chemical Probes and Illuminate Ubiquitin BiologyR01GM067945 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI GYGI, STEVEN P · 2003 to 2024
$10.5M
Howard Hughes Medical InstituteNHLBI NIH HHS T32 HL007627NIGMS NIH HHS R01 GM067945NIGMS NIH HHS T32 GM007287
6 · The paper itself

Abstract

Little is known about how human Y-Chromosome gene expression directly contributes to differences between XX (female) and XY (male) individuals in nonreproductive tissues. Here, we analyzed quantitative profiles of Y-Chromosome gene expression across 36 human tissues from hundreds of individuals. Although it is often said that Y-Chromosome genes are lowly expressed outside the testis, we report many instances of elevated Y-Chromosome gene expression in a nonreproductive tissue. A notable example is

Indexed as

Chromosomes, Human, YGene Expression ProfilingGene Expression RegulationGenes, Y-LinkedTranscriptomeChromosomes, Human, XComputational BiologyEvolution, MolecularFemaleGenes, X-LinkedHumansMaleMicroRNAsOrgan SpecificityMicroRNAs

Identifiers

PMID32461223
PMCPMC7370882
OpenAlexW3028862074

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.