Evidence map›Paper›PMID 32461211›Full record

Observational studyDiabetes care2020

The Relationship Between CGM-Derived Metrics, A1C, and Risk of Hypoglycemia in Older Adults With Type 1 Diabetes.

Elena Toschi, Christine Slyne, Kayla Sifre, Rachel O'Donnell, Jordan Greenberg, Astrid Atakov-Castillo, Sam Carl, Medha Munshi

Erratum issuedOpen access · greenAbstract readObservational Study
In one paragraph

Observational study in Diabetes care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Narrative Review: Continuous Glucose Monitoring (CGM) in Older Adults with Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025
    Review
  9. Article
  10. Review
  11. Individualized treatment of diabetes mellitus in older adults.Geriatrics & gerontology international · 2024
    Review
  12. Unveiling the Spectrum of Glucose Variability: A Novel Perspective on FreeStyle Libre Monitoring Data.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024
    Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Observational
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Elena ToschiJoslin Diabetes Center, Boston, MA elena.toschi@joslin.harvard.edu.ORCID 0000-0003-4077-1160
Christine SlyneJoslin Diabetes Center, Boston, MA.
Kayla SifreJoslin Diabetes Center, Boston, MA.
Rachel O'DonnellJoslin Diabetes Center, Boston, MA.
Jordan GreenbergJoslin Diabetes Center, Boston, MA.
Astrid Atakov-CastilloJoslin Diabetes Center, Boston, MA.
Sam CarlJoslin Diabetes Center, Boston, MA.
Medha MunshiJoslin Diabetes Center, Boston, MA.ORCID 0000-0001-6917-4197
Joslin Diabetes Center · US

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
Use of Continuous Glucose Monitoring with Automated Clinical Decision Support to Reduce Hypoglycemia in Older Adults with Type 1 DiabetesDP3DK112214 · NIDDK · JOSLIN DIABETES CENTER · PI MUNSHI, MEDHA N, STEIL, GARRY MICHAEL · 2016 to 2016
$4.0M
NIDDK NIH HHS DP3 DK112214NIDDK NIH HHS P30 DK036836
6 · The paper itself

Abstract

objectiveContinuous glucose monitoring (CGM) is now commonly used in the management of type 1 diabetes (T1D). The CGM-derived coefficient of variation (CV) measures glucose variability, and the glucose management indicator (GMI) measures mean glycemia (previously called estimated A1C). However, their relationship with laboratory-measured A1C and the risk of hypoglycemia in older adults with T1D is not well studied. RESEARCH DESIGN AND

methodsIn a single-center study, older adults (age ≥65 years) with T1D wore a CGM device for 14 days. The CV (%) and GMI were calculated, and A1C and clinical and demographic information were collected.

resultsWe evaluated 130 older adults (age 71 ± 5 years), of whom 55% were women, 97% were White, diabetes duration was 39 ± 17 years, and A1C was 7.3 ± 0.6% (56 ± 15 mmol/mol). Participants were stratified by high CV (>36%;

conclusionsIn older adults with T1D, the use of CGM-derived CV and GMI can better identify individuals at higher risk for hypoglycemia compared with A1C alone. These measures should be combined with A1C for better diabetes management in older adults with T1D.

Indexed as

Data AccuracyDiabetes Mellitus, Type 1Glycated HemoglobinGlycemic ControlHypoglycemiaAgedAged, 80 and overAge FactorsBlood GlucoseBlood Glucose Self-MonitoringCohort StudiesData Interpretation, StatisticalFemaleHumansMaleMiddle AgedBlood GlucoseGlycated Hemoglobin

Identifiers

PMID32461211
PMCPMC7510030
OpenAlexW3030349710

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.