Evidence map›Paper›PMID 32461127›Full record

ArticleBehavioural brain research2020

Inhibition of striatal-enriched protein tyrosine phosphatase (STEP) activity reverses behavioral deficits in a rodent model of autism.

Manavi Chatterjee, Priya Singh, Jian Xu, Paul J Lombroso, Pradeep K Kurup

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural brain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Manavi ChatterjeeChild Study Center, Yale University, 230 South Frontage Rd, New Haven, CT 06520, United States; Department of Pharmacology, Yale University, 333 Cedar Street, New Haven, CT 06520, United States. Electronic address: manavi.chatterjee@yale.edu.
Priya SinghChild Study Center, Yale University, 230 South Frontage Rd, New Haven, CT 06520, United States.
Jian XuChild Study Center, Yale University, 230 South Frontage Rd, New Haven, CT 06520, United States; Department of Psychiatry, Yale University, 333 Cedar Street, New Haven, CT 06520, United States.
Paul J LombrosoChild Study Center, Yale University, 230 South Frontage Rd, New Haven, CT 06520, United States; Department of Psychiatry, Yale University, 333 Cedar Street, New Haven, CT 06520, United States; Department of Neuroscience, Yale University, 333 Cedar Street, New Haven, CT 06520, United States.
Pradeep K KurupChild Study Center, Yale University, 230 South Frontage Rd, New Haven, CT 06520, United States; Department of Surgery, University of Alabama at Birmingham, 1900 University Blvd, Birmingham, AL 35233, United States. Electronic address: pkurup@uabmc.edu.
Yale University · US

Funding

MOLECULAR AND CELLULAR ANALYSIS OF BRAIN ENRICHED PTPSR01MH052711 · NIMH · YALE UNIVERSITY · PI LOMBROSO, PAUL J · 1999 to 2014
$5.0M
The Role of STEP in SchizophreniaR01MH091037 · NIMH · YALE UNIVERSITY · PI LOMBROSO, PAUL J · 2011 to 2015
$1.8M
NIMH NIH HHS R01 MH052711NIMH NIH HHS R01 MH091037
6 · The paper itself

Abstract

Autism spectrum disorders (ASDs) are highly prevalent childhood illnesses characterized by impairments in communication, social behavior, and repetitive behaviors. Studies have found aberrant synaptic plasticity and neuronal connectivity during the early stages of brain development and have suggested that these contribute to an increased risk for ASD. STEP is a protein tyrosine phosphatase that regulates synaptic plasticity and is implicated in several cognitive disorders. Here we test the hypothesis that STEP may contribute to some of the aberrant behaviors present in the VPA-induced mouse model of ASD. In utero VPA exposure of pregnant dams results in autistic-like behavior in the pups, which is associated with a significant increase in the STEP expression in the prefrontal cortex. The elevated STEP protein levels are correlated with increased dephosphorylation of STEP substrates GluN2B, Pyk2 and ERK, suggesting upregulated STEP activity. Moreover, pharmacological inhibition of STEP rescues the sociability, repetitive and abnormal anxiety phenotypes commonly associated with ASD. These data suggest that STEP may play a role in the VPA model of ASD and STEP inhibition may have a potential therapeutic benefit in this model.

Indexed as

AnimalsAutism Spectrum DisorderAutistic DisorderBehavior, AnimalDisease Models, AnimalExploratory BehaviorFemaleInhibition, PsychologicalMaleMiceMice, Inbred C57BLNeuronal PlasticityPrefrontal CortexPregnancyPrenatal Exposure Delayed EffectsProtein Tyrosine PhosphatasesProtein Tyrosine PhosphatasesProtein Tyrosine Phosphatases, Non-ReceptorPTPN5 protein, humanValproic AcidAutismRepetitive behaviorSocial interactionSTEPTC-2153Valproic acid

Identifiers

PMID32461127
PMCPMC7346720
OpenAlexW3027223251

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.